Human alcohol-related neuropathology
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TLDR
Further progress is needed to better understand the pathophysiology of this exposure-related constellation of nervous system diseases and better correlate the underlying pathology with in vivo imaging and biochemical lesions.Citations
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Neuroimmune signaling in alcohol use disorder
TL;DR: An overview of major neuroimmune cell‐types and pathways involved in mediating alcohol behaviors are provided, potential mechanisms of alcohol‐induced neuroimmune activation are discussed, and recent clinical evidence for candidate immune‐related drugs to treat AUD is presented.
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Using zebrafish in systems toxicology for developmental toxicity testing.
Yuhei Nishimura,Atsuto Inoue,Shota Sasagawa,Junko Koiwa,Koki Kawaguchi,Reiko Kawase,Toru Maruyama,Soonih Kim,Toshio Tanaka +8 more
TL;DR: Zebrafish as a systems toxicology model has the potential to elucidate developmental toxicity pathways, and to provide a sound basis for human health risk assessments.
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Advances in clinical determinants and neurological manifestations of B vitamin deficiency in adults.
TL;DR: The interrelationships of multiple B vitamin deficiencies are emphasized, along with the clinical phenotypes related to Bitamin deficiencies, and the suggested therapies for B vitamin disorders are described.
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Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis
Vugar Azizov,Katharina Dietel,Franziska Steffen,Kerstin Dürholz,Julia Meidenbauer,Sébastien Lucas,Michael Frech,Yasunori Omata,Narges Tajik,Lisa Knipfer,Anne Kolenbrander,Silvia Seubert,Dennis Lapuente,Maria V. Sokolova,Jörg Hofmann,Matthias Tenbusch,Andreas Ramming,Ulrike Steffen,Falk Nimmerjahn,Ralf A. Linker,Stefan Wirtz,Martin Herrmann,Vladimir Temchura,Kerstin Sarter,Georg Schett,Mario M. Zaiss +25 more
TL;DR: It is shown that ethanol and its metabolite acetate can protect mice from collagen-induced arthritis and evidence is provided that the mechanism of this effect might be via inhibition of the effector function of T follicular helper cells.
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Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury.
TL;DR: In this article, a review of the properties of AGEs: their formation, accumulation, and receptor interactions, and their causative functions that impact various aging-related diseases.
References
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Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Bin Gao,Ramon Bataller +1 more
TL;DR: Findings from recent studies that have characterized specific intracellular signaling pathways, transcriptional factors, aspects of innate immunity, chemokines, epigenetic features, microRNAs, and stem cells that are associated with ALD are reviewed, improving the understanding of its pathogenesis.
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Hemorrhages into peripheral nerves in association with leukemia.
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Eccrine spiradenoma. An electron microscopic study.
TL;DR: Based on observations, eccrine spiradenoma appears to differentiate toward ductal structures of eccrine sweat apparatus.
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Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management
TL;DR: The optimum dose of parenteral thiamine required for prophylaxis and treatment of Wernicke's encephalopathy and prevention of Korsakoff's syndrome associated with alcohol misuse is emphasised.
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Economic Costs of Excessive Alcohol Consumption in the U.S., 2006
TL;DR: In this article, the authors followed U.S. Public Health Service Guidelines to assess the economic cost of excessive alcohol consumption in 2006 and found that excessive drinking causes premature death (average of 79,000 deaths annually), increased disease and injury; property damage from fire and motor vehicle crashes; alcoholrelated crime; and lost productivity.