Journal ArticleDOI
Human choroid plexus: a light and electron microscopic study
George J. Dohrmann,Paul C. Bucy +1 more
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In choroid plexuses of older humans, filaments from 60 to 150 A in diameter, with no apparent periodicity, were noted circumjacent to the intracytoplasmic inclusions, and each inclusion type predominated in a particular age group.Abstract:
✓ Specimens of human choroid plexus, obtained during craniotomy, were examined by light and electron microscopy. Inclusions were observed within the cytoplasm of the choroidal epithelial cells, and could be classified into three types on the basis of morphological characteristics. Each inclusion type predominated in a particular age group. In choroid plexuses of older humans, filaments from 60 to 150 A in diameter, with no apparent periodicity, were noted circumjacent to the intracytoplasmic inclusions.read more
Citations
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Journal ArticleDOI
Cerebrospinal Fluid Secretion by the Choroid Plexus
TL;DR: This review focuses on the specific ion and water transport by the choroid plexus cells, and then attempts to integrate the action of specific transport proteins to formulate a model of cerebrospinal fluid secretion.
Journal ArticleDOI
Protein size and cerebrospinal fluid composition.
TL;DR: The concentration ratios of several proteins between serum and cerebrospinal fluid (CSF) can be correlated more easily to hydrodynamic volumes than to molweights, especially with the high-molecular proteins.
Journal ArticleDOI
The development and functions of multiciliated epithelia
Nathalie Spassky,Alice Meunier +1 more
TL;DR: This Review provides a cell-to-organ overview of multiciliated cells and highlight recent studies that have greatly increased the understanding of the mechanisms driving the development and function of these cells in vertebrates.
Journal ArticleDOI
Human CNS barrier-forming organoids with cerebrospinal fluid production
Laura Pellegrini,Claudia Bonfio,Jessica Chadwick,Farida Begum,Mark Skehel,Madeline A. Lancaster +5 more
TL;DR: It is demonstrated that organoids can qualitatively and quantitatively predict the permeability of new drugs, and is taken advantage of this system to reveal a potential toxic accumulation of BIA 10-2474, a drug that caused severe neurotoxicity only in humans and not in animal models tested.
Book ChapterDOI
Structural aspects of brain barriers, with special reference to the permeability of the cerebral endothelium and choroidal epithelium.
TL;DR: One possible pathway across the cerebral endothelium for larger hydrophilic molecules appears to be vesicular transport comparable with that occurring in normal noncerebral tissue, indicative of the presence of a labile pore system in the cerebral microvasculature.
References
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