Journal ArticleDOI
Hydrogen sulfide as an endogenous regulator of vascular smooth muscle tone in trout
TLDR
Because NaHS has substantial vasoactive effects at physiological plasma concentrations, it is proposed that its soluble derivative, H(2)S, is a tonically active endogenous vasoregulator in trout.Abstract:
Hydrogen sulfide (H2S) is an endogenous vasodilator in mammals, but its presence and function in other vertebrates is unknown. We generated H2S from NaHS and examined the effects on isolated effere...read more
Citations
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Journal ArticleDOI
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
TL;DR: The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrate, vertebrates, and finally to mammals, but over the centuries it had only been known for its toxicity and environmental hazard.
Journal ArticleDOI
H2S signalling through protein sulfhydration and beyond
Bindu D. Paul,Solomon H. Snyder +1 more
TL;DR: Physiological actions of sulfhydration include the regulation of inflammation and endoplasmic reticulum stress signalling as well as of vascular tension.
Journal ArticleDOI
Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria.
TL;DR: H(2)S enhances the transport of cysteine to increase GSH production more than cystine transport and to redistribute the localization of GSH to mitochondria and provides a new mechanism of neuroprotection from oxidative stress by H( 2)S.
Journal Article
Hydrogen sulfide (H2S) - the third gas of interest for pharmacologists.
Ewelina Łowicka,Jerzy Bełtowski +1 more
TL;DR: Hydrogen sulfide (H(2)S) is involved in the regulation of vascular tone, myocardial contractility, neurotransmission, and insulin secretion, and reduction of its production may be of potential therapeutic value in these states.
Journal ArticleDOI
A source of hydrogen sulfide and a mechanism of its release in the brain.
TL;DR: It is shown that H2S is released from bound sulfur, an intracellular store of sulfur, in neurons and astrocytes of mice and rats in the presence of physiologic concentrations of endogenous reducing substances glutathione and cysteine.
References
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Journal ArticleDOI
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
TL;DR: It is demonstrated that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.
Journal ArticleDOI
The possible role of hydrogen sulfide as an endogenous neuromodulator
Kazuho Abe,Hideo Kimura +1 more
TL;DR: It is shown that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation, suggesting that endogenous H 2S functions as a neuromodulator in the brain.
Journal ArticleDOI
The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
TL;DR: It is demonstrated that H2S is an important endogenous vasoactive factor and the first identified gaseous opener of KATP channels in vascular SMCs and production from vascular tissues was enhanced by nitric oxide.
Journal ArticleDOI
Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter?
TL;DR: It is hypothesized that H2S is the third endogenous signaling gasotransmitter, besides nitric oxide and carbon monoxide, and this positioning will open an exciting field‐H2S physiology‐encompassing realization of the interaction of H1N1 and other gasOTransmitters, sulfurating modification of proteins, and the functional role of H2Sin multiple systems.
Journal ArticleDOI
The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.
TL;DR: In this paper, the authors showed that mRNA for another H2S producing enzyme, cystathionine gamma-lyase, is expressed in the ileum, portal vein, and thoracic aorta.
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The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
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