Journal ArticleDOI
Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering.
Chengtie Wu,Yinghong Zhou,Wei Fan,Wei Fan,Pingping Han,Jiang Chang,Jones Yuen,Meili Zhang,Yin Xiao +8 more
TLDR
The results showed that low amounts of Co (<5%) incorporated into MBG scaffolds had no significant cytotoxicity and that their incorporation significantly enhanced VEGF protein secretion, HIF-1α expression, and bone-related gene expression in BMSCs, and also that the Co-MBG scaffolding support BMSC attachment and proliferation.About:
This article is published in Biomaterials.The article was published on 2012-03-01. It has received 361 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
Citations
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Review of bioactive glass: from Hench to hybrids.
TL;DR: The paper takes the reader from Hench's Bioglass 45S5 to new hybrid materials that have tailorable mechanical properties and degradation rates, covering the importance of control of hierarchical structure, synthesis, processing and cellular response in the quest for new regenerative synthetic bone grafts.
Journal ArticleDOI
Recent advances in bone tissue engineering scaffolds.
TL;DR: In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.
Journal ArticleDOI
Bone grafts and biomaterials substitutes for bone defect repair: A review.
Wenhao Wang,Kelvin W.K. Yeung +1 more
TL;DR: The currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect are reviewed.
Journal ArticleDOI
Scaffold Design for Bone Regeneration
TL;DR: This focus of this review is on the evolution of these scaffolds as bone graft substitutes in the process of recreating the bone tissue microenvironment, including biochemical and biophysical cues.
Journal ArticleDOI
Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity
TL;DR: In this paper, a copper-containing mesoporous bioactive glass (Cu-MBG) scaffolds with interconnective large pores (several hundred micrometer) and well-ordered mesopore channels (around 5 nm) were used to develop multifunctional bioactive scaffolds, which combine angiogenesis capacity, osteostimulation, and antibacterial properties for regenerating lost bone tissues.
References
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Journal ArticleDOI
Scaffolds in tissue engineering bone and cartilage.
TL;DR: Research on the tissue engineering of bone and cartilage from the polymeric scaffold point of view is reviews from a biodegradable and bioresorbable perspective.
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The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
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Mesoporous materials for drug delivery.
TL;DR: This Minireview deals with the advances in this field by the control of the textural parameters, surface functionalization, and the synthesis of sophisticated stimuli-response systems.
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Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family
Kirsty S. Hewitson,Luke A McNeill,Madeline V. Riordan,Ya-Min Tian,Alex N. Bullock,Richard W.D. Welford,Jonathan M. Elkins,Neil J. Oldham,Shoumo Bhattacharya,Jonathan M. Gleadle,Peter J. Ratcliffe,Christopher W. Pugh,Christopher J. Schofield +12 more
TL;DR: Assays using recombinant FIH and HIF-α fragments revealed that FIH is the enzyme that hydroxylates the CAD asparagine residue, that the activity is directly inhibited by cobalt(II) and limited by hypoxia, and that the oxygen in the alcohol of the hydroxyasparagine residues is directly derived from dioxygen.