Journal ArticleDOI
I-region-associated determinants: expression on mitogen-stimulated lymphocytes and detection by cytotoxic T cells
M. Nabholz,H. Young,A. Rynbeek,R. Boccardo,Chella S. David,Tommaso Meo,Tommaso Meo,V. Miggiano,V. Miggiano,D. C. Shreffler +9 more
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TLDR
Lysis by killer cells can also be obtained against incompatibilities which do not give rise to strong skin graft rejection and against determinants which are most probably controlled by genes outside the K‐D interval.Abstract:
We have studied the expression of Ia-antigens, controlled by genes in the I-region of the H-2 complex, on phytohemagglutinin (PHA)-stimulated lymph node cells and on lipopolysaccharide (LPS)-stimulated spleen cells, and have compared these two types of cell populations as targets for killer cells in the cell mediated lympholysis (CML) assay. PHA targets are almost completely insensitive to complement-mediated lysis by anti-Ia sera while the majority of LPS targets are killed. T cell-mediated lysis against I-region determinants was also detected, and these determinants, in contrast to H-2K and H-2D CML determinants, seem to be much more strongly expressed on LPS-stimulated cells. No differences in the kinetics of the response to K- or I-region CML determinants were observed. Lysis by killer cells can also be obtained against incompatibilities which do not give rise to strong skin graft rejection and against determinants which are most probably controlled by genes outside the K-D interval.read more
Citations
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Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.
Lynda A. Morrison,Aron E. Lukacher,Vivian L. Braciale,David P. Fan,David P. Fan,T J Braciale +5 more
TL;DR: Treatment of the target cells with the lysosomotropic agent chloroquine abolished recognition of infected target cells by class II-restricted CTL without diminishing class I-restricted recognition ofinfected target cells, suggesting that important differences may exist in requirements for antigen presentation between H-2K/D and H- 2I region- restricted CTL.
Book ChapterDOI
Immune Response(Ir)Genes of the Murine Major Histocompatibility Complex
TL;DR: This chapter opens up with a detailed analysis of the early experiments of these scientists, culminating in the discovery by McDevitt that these genes were linked to the major histocompatibility complex (MHC).
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The Major Histocompatibility System in Man and Animals
TL;DR: One that the authors will refer to break the boredom in reading is choosing the major histocompatibility system in man and animals as the reading material.
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Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes.
TL;DR: Regulatory effects of alloantigen-activated thymus-derived lymphocytes in mixed lymphocyte reactions have been demonstrated and splenic suppressor cell generation in vivo revealed peak activity four days after allOantigen stimulation with no activity demonstrable at 7 days or at later times.
References
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Book ChapterDOI
The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.
TL;DR: This chapter discusses the immune response region, the genes of which appear to control a variety of immune phenomena—including antibody response to many antigens, susceptibility to tumor viruses, and graft-versus-host (GVH), and mixed lymphocyte culture (MLC) reactions.
Journal ArticleDOI
A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.
David H. Sachs,James L. Cone +1 more
TL;DR: It seems possible that there may be a variety of H-2-linked alloantigens expressed preferentially on subclasses of lymphocytes, as reactions with recombinant strains of mice indicate that the cell-surface antigen responsible for this specificity is determined by gene in or to the left of the Ir-1 region of the major histocompatibility complex.
Journal ArticleDOI
New Lymphocyte Antigen System (Lna) Controlled by the Ir Region of the Mouse H-2 Complex
TL;DR: A new system of lymphocyte alloantigens in mice is described and may be of value for definition and characterization of the products of the Ir and MLR (mixed lymphocyte reaction stimulatory) genes associated with the H-2 complex.
Journal ArticleDOI
Cell-mediated cell lysis in vitro: genetic control of killer cell production and target specificities in the mouse.
M. Nabholz,J. Vives,Hazel M. Young,T. Meo,V. C. Miggiano,Anne-Marie Rijnbeek,D. C. Shreffler +6 more
TL;DR: The requirements for killer cell production in the course of a mixed leukocyte reaction and the specificity of target cell lysis in the mouse were investigated using inbred strains carrying intra‐H‐2 recombinant chromosomes.
Journal ArticleDOI
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes
Jeffrey A. Frelinger,Jeffrey A. Frelinger,John E. Niederhuber,Chella S. David,Donald C. Shreffler +4 more
TL;DR: In vivo absorptions in BALB/c nude cannot remove all of the cytotoxic activity for normal BALB lymph node lymphocytes, while completely removing the activity for nude cells.
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The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.
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