Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle.
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TLDR
It is demonstrated that 1,25-(OH)2D3 can inhibit DNA synthesis and cell proliferation of the G-8 myoblast cells in a dose-dependent manner and the possibility that muscle is a target tissue for 1, 25-dihydroxyvitamin D3 and the hormone may act to initiate terminal differentiation of myOBlast cells is supported.About:
This article is published in Journal of Biological Chemistry.The article was published on 1985-07-25 and is currently open access. It has received 468 citations till now. The article focuses on the topics: Receptor & Myocyte.read more
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Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
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Vitamin D deficiency : a worldwide problem with health consequences
Michael F. Holick,Tai C. Chen +1 more
TL;DR: Vitamin D deficiency causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults, and foods that are fortified with vitamin D are often inadequate to satisfy either a child's or an adult's vitamin D requirement.
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High prevalence of vitamin D inadequacy and implications for health.
TL;DR: The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health.
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The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis
TL;DR: Evidence from trials with vitamin D and/or calcium supplementation suggests that combined Vitamin D and calcium supplementation may have a role in the prevention of type 2 DM only in populations at high risk (i.e. glucose intolerance).
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Fracture Prevention With Vitamin D Supplementation: A Meta-analysis of Randomized Controlled Trials
Heike A. Bischoff-Ferrari,Walter C. Willett,John B. Wong,Edward Giovannucci,Thomas Dietrich,Bess Dawson-Hughes +5 more
TL;DR: Oral vitamin D supplementation between 700 to 800IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons and an oral vitamin D dose of 400 IU/d is not sufficient for fracture prevention.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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Ligand: a versatile computerized approach for characterization of ligand-binding systems.
Peter J. Munson,David Rodbard +1 more
TL;DR: This approach provides two major advantages compared with other available methods: it uses an exact mathematical model of the ligand-binding system, thereby avoiding the possible biases introduced by several commonly used approximations and it uses a statistically valid, appropriately weighted least-squares curve-fitting algorithm with objective measurement of goodness of fit.
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Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3
Etsuko Abe,Chisato Miyaura,Hiroshi Sakagami,Minoru Takeda,Kunio Konno,Tohru Yamazaki,Shusaku Yoshiki,Tatsuo Suda +7 more
TL;DR: The results suggest the possibility that, in addition to its wellknown biological activities in enhancing intestinal calcium transport and bone mineral mobilization, 1 alpha, 25-dihydroxyvitamin D3 is involved in the differentiation of bone marrow cells.