Journal ArticleDOI
Image-guided Biopsy: What the Interventional Radiologist Needs to Know about PET/CT
Katsuhiro Kobayashi,Peeyush Bhargava,Shanker Raja,Farbod Nasseri,Hassan Al-Balas,Hassan Al-Balas,Darryl D. Smith,Sharad George,Meena S. Vij +8 more
TLDR
To properly select patients for image-guided biopsy, interventional radiologists should be familiar with the biologic significance ofFDG uptake and various causes of false-positive and false-negative FDG uptake.Abstract:
Positron emission tomography (PET)/computed tomography (CT) with fluorine 18 fluorodeoxyglucose (FDG) is increasingly used in evaluation of oncology patients. Because PET/CT can demonstrate malignancy before morphologic changes are evident, application of PET/CT information to image-guided biopsy can facilitate early histologic diagnosis and staging. However, because FDG uptake is not specific to cancer, PET/CT findings may raise questions about whether uptake in a lesion is an indication for biopsy. To properly select patients for image-guided biopsy, interventional radiologists should be familiar with the biologic significance of FDG uptake and various causes of false-positive uptake. PET/CT images may also become a source of confusion in the interpretation of biopsy results. Various causes of false-positive and false-negative FDG uptake need to be considered, especially when there is a discrepancy between biopsy results and PET/CT findings. False-negative FDG uptake can result from cancers that are too small to be observed or not FDG avid. False-positive FDG uptake can be due to underlying inflammation from recent treatment. Conversely, complete resolution of FDG uptake in a treated lesion does not necessarily indicate absence of viable cells. When questions about PET/CT findings arise in the context of image-guided biopsy, discussion with experienced nuclear imaging physicians is essential.read more
Citations
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Anti-1-Amino-3-18F-Fluorocyclobutane-1-Carboxylic Acid: Physiologic Uptake Patterns, Incidental Findings, and Variants That May Simulate Disease
David M. Schuster,Cristina Nanni,Stefano Fanti,Shuntaro Oka,Hiroyuki Okudaira,Yusuke Inoue,Jens Nørkær Sørensen,Rikard Owenius,Peter L. Choyke,Baris Turkbey,Trond Velde Bogsrud,Tore Bach-Gansmo,Raghuveer Halkar,Jonathon A. Nye,Oluwaseun Odewole,Bital Savir-Baruch,Mark M. Goodman +16 more
TL;DR: Though 18F-FACBC exhibited little renal excretion or bladder uptake during the clinically useful early imaging time window, mild to moderate activity might accumulate in the bladder and interfere with evaluation of adjacent prostate bed and seminal vesicles in 5%–10% of patients.
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Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Wei Wu,Jessica L. Klockow,Michael Zhang,Famyrah Lafortune,Edwin Chang,Linchun Jin,Yang Wu,Heike E. Daldrup-Link +7 more
TL;DR: In this paper, the authors describe biological and molecular targets for GBM therapy, the current status of pharmacologic therapy, prominent mechanisms of resistance, and new treatment approaches, and the standard treatment for GBMs is surgical resection followed by chemoradiotherapy.
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Accuracy and efficacy of percutaneous biopsy and ablation using robotic assistance under computed tomography guidance: a phantom study
TL;DR: Improved needle accuracy and optimised probe geometry are observed during simulated CT-guided biopsy and percutaneous ablation with use of a robotic IR assistance platform.
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Advances in medical imaging for the diagnosis and management of common genitourinary cancers.
Mohammad Hadi Bagheri,Mark A. Ahlman,Liza Lindenberg,Baris Turkbey,Jeffrey Lin,Ali Cahid Civelek,Ashkan A. Malayeri,Piyush K. Agarwal,Peter L. Choyke,Les R. Folio,Andrea B. Apolo +10 more
TL;DR: Functional and molecular imaging using 18-fluorodeoxyglucose-PET and sodium fluoride-PET are essential for the diagnosis, and especially follow-up, of metastatic GU tumors.
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Performance of intra-procedural 18-fluorodeoxyglucose PET/CT-guided biopsies for lesions suspected of malignancy but poorly visualized with other modalities.
François Cornelis,Mikhail Silk,Heiko Schöder,H. Takaki,Jeremy C. Durack,Joseph P. Erinjeri,Constantinos T. Sofocleous,R.H. Siegelbaum,Majid Maybody,Stephen B. Solomon +9 more
TL;DR: Intra-procedural PET/CT guidance appears as a safe and effective method and allows high diagnostic success of percutaneous biopsies for metabolically active lesions.
References
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Journal Article
Intratumoral Distribution of Fluorine-18-Fluorodeoxyglucose In Vivo: High Accumulation in Macrophages and Granulation Tissues Studied by Microautoradiography
TL;DR: The results showed that one should consider not only the tumor cells proper but also the non-neoplastic cellular elements, which appear in association with growth or necrosis of the tumor Cells, for precise analysis of [18F]FDG uptake in tumor-bearing subjects, especially after anti-NEoplastic treatment.
Journal ArticleDOI
18-fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation.
Hongming Zhuang,Abass Alavi +1 more
TL;DR: Because of its ability to quantitate the rate of FDG uptake, PET may prove to be a powerful modality for the monitoring of disease activity and response to therapy.
Journal Article
Does FDG Uptake Measure Proliferative Activity of Human Cancer Cells? In Vitro Comparison with DNA Flow Cytometry and Tritiated Thymidine Uptake
TL;DR: In vitro differences in tracer uptake suggest that in this adenocarcinoma cell line, FDG measures a substantially different parameter (viable cell number) than thymidine (proliferative rate) and that these differences may result in disparate findings on PET imaging of cancers using these two tracers.
Journal ArticleDOI
False-Positive FDG PET Uptake−the Role of PET/CT
TL;DR: Combined PET and CT improves the diagnostic accuracy compared to PET alone and helps to avoid unnecessary surgery/therapy, however, PET/CT involves other sources of artifacts that may occur when using CT for attenuation correction of PET or by patient motion caused by respiration or bowel movements.
Journal ArticleDOI
Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography.
Mark S. Cohen,Nuri Arslan,Farrokh Dehdashti,Gerard M. Doherty,Terry C. Lairmore,L. M. Brunt,Jeffrey F. Moley +6 more
TL;DR: Patients with new thyroid lesions on PET scan should have a tissue diagnosis if it will influence outcome and management, and standardized uptake values may be helpful in predicting benign versus malignant histology.