Imaging lung perfusion.
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TLDR
The goal of this review is to give an overview of the techniques most commonly in use for physiological experiments along with the issues unique to each technique.Abstract:
From the first measurements of the distribution of pulmonary blood flow using radioactive tracers by West and colleagues (J Clin Invest 40: 1–12, 1961) allowing gravitational differences in pulmona...read more
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Magnetic resonance imaging detects changes in structure and perfusion, and response to therapy in early cystic fibrosis lung disease.
Mark O. Wielpütz,Michael Puderbach,Annette Kopp-Schneider,Mirjam Stahl,Eva Fritzsching,Olaf Sommerburg,Sebastian Ley,Migle Sumkauskaite,Jürgen Biederer,Hans-Ulrich Kauczor,Monika Eichinger,Marcus A. Mall +11 more
TL;DR: In this paper, the potential of MRI to detect abnormal lung structure and perfusion in infants and preschool children with CF, and to monitor the response to therapy for pulmonary exacerbation was evaluated.
Journal ArticleDOI
Imaging of Cystic Fibrosis Lung Disease and Clinical Interpretation.
Mark O. Wielpütz,Michael Eichinger,Jürgen Biederer,Sabine Wege,Mirjam Stahl,Olaf Sommerburg,Marcus A. Mall,Marcus A. Mall,Hans-Ulrich Kauczor,Michael Puderbach +9 more
TL;DR: Changing to CT was inseparably accompanied by an increase in radiation exposure of CF patients, a young population with high sensitivity to ionizing radiation and lifetime accumulation of dose, which led to a significant improvement in survival.
Journal ArticleDOI
Expanding Applications of Pulmonary MRI in the Clinical Evaluation of Lung Disorders: Fleischner Society Position Paper.
Hiroto Hatabu,Yoshiharu Ohno,Warren B. Gefter,Grace Parraga,Bruno Madore,Kyung Soo Lee,Talissa A. Altes,David A. Lynch,John R. Mayo,Joon Beom Seo,Jim M. Wild,Edwin J R van Beek,Mark L. Schiebler,Hans-Ulrich Kauczor +13 more
TL;DR: This Fleischner Society position paper familiarize radiologists and other interested clinicians with advances in pulmonary MRI and stratify the Society recommendations for the clinical use of pulmonary MRI into three categories: suggested for current clinical use, promising but requiring further validation or regulatory approval, and appropriate for research investigations.
Journal ArticleDOI
Multicentre standardisation of chest MRI as radiation-free outcome measure of lung disease in young children with cystic fibrosis.
Mark O. Wielpütz,Oyunbileg von Stackelberg,Mirjam Stahl,Bertram J. Jobst,Monika Eichinger,Michael Puderbach,Lutz Nährlich,Sandra Barth,Christian Schneider,Matthias V. Kopp,Isabell Ricklefs,Michael Buchholz,Burkhard Tümmler,Burkhard Tümmler,Christian Dopfer,Christian Dopfer,Jens Vogel-Claussen,Jens Vogel-Claussen,Hans-Ulrich Kauczor,Marcus A. Mall +19 more
TL;DR: The results demonstrate that multicentre standardisation of chest MRI is feasible and support its use as radiation-free outcome measure of lung disease in infants and preschool children with CF.
References
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Effective Doses in Radiology and Diagnostic Nuclear Medicine: A Catalog
TL;DR: Effective dose provides an approximate indicator of potential detriment from ionizing radiation and should be used as one parameter in evaluating the appropriateness of examinations involving ionizing Radiation.
Journal Article
The theory and applications of the exchange of inert gas at the lungs and tissues
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Material differentiation by dual energy CT: initial experience
Thorsten R. C. Johnson,Bernhard Dr. Krauß,Martin Sedlmair,Martin Sedlmair,Michael Grasruck,Herbert Bruder,Dominik Morhard,Christian Fink,Sabine Weckbach,Miriam Lenhard,Bernhard Schmidt,Thomas Flohr,Maximilian F. Reiser,Christoph R. Becker +13 more
TL;DR: Results showed that a differentiation and depiction of contrast material distribution is possible in the brain, the lung, the liver and the kidneys with or without the underlying tissue of the organ, and Dual energy CT offers a more specific tissue characterization in CT and can improve the assessment of vascular disease.
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Exposure to Low-Dose Ionizing Radiation from Medical Imaging Procedures
Reza Fazel,Harlan M. Krumholz,Yongfei Wang,Joseph S. Ross,Jersey Chen,Henry H. Ting,Nilay Shah,Khurram Nasir,Khurram Nasir,Andrew J. Einstein,Andrew J. Einstein,Brahmajee K. Nallamothu,Brahmajee K. Nallamothu +12 more
TL;DR: Imaging procedures are an important source of exposure to ionizing radiation in the United States and can result in high cumulative effective doses of radiation, which increased with advancing age and were higher in women than in men.
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Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures.
TL;DR: The left lung from a dog was removed, ventilated with negative pressure, and perfused with venous blood to establish pulmonary arterial, venous, and alveolar pressures that could be varied over a large range.