Journal ArticleDOI
Immunohistological Evidence for Renin in Human Endocrine Tissues
K. Naruse,Murakoshi M,Osamura Ry,Mitsuhide Naruse,H Toma,Keiichi Watanabe,Hiroshi Demura,Tadashi Inagami,Kazuo Shizume +8 more
TLDR
Renin immunoreactivity was found in some large cells of the anterior pituitary, theZona glomerulosa and the zona reticularis of the adrenal, the Leydig cells ofthe testis, and the follicular epithelial cells ofThe thyroid and prostate glands.Abstract:
The peroxidase-labeled antibody method and the avidin-biotin-complex method with antiserum to purified human kidney renin were used to identify renin in humanendocrine tissues. Renin immunoreactivity was found in some large cells of the anterior pituitary, the zona glomerulosa and the zona reticularis of the adrenal, the Leydig cells of the testis, and the follicular epithelial cells of the thyroid and prostate glands. The specificity of the immunohistochemical reaction was confirmed by immunoabsorption tests. The specific localization of immunoreactive renin in each tissue suggests a possible role of renin in the function of these tissues.read more
Citations
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Journal ArticleDOI
Physiology of local renin-angiotensin systems.
TL;DR: A large body of data is now available to support the existence of numerous organ-based RAS exerting diverse physiological effects, and universal paracrine and autocrine actions may be important in many organ systems and can mediate important physiological stimuli.
Journal ArticleDOI
Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment
TL;DR: I. Introduction II.
Journal ArticleDOI
Prorenin in high concentrations in human ovarian follicular fluid
TL;DR: The ovary is a likely source for the ovulatory peak of plasma prorenin, the precursor of renin, which was measured in fluid aspirated from 18 ovarian follicles and in plasma collected from three women who were undergoing in vitro fertilization.
Journal ArticleDOI
Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins.
I Kifor,Victor J. Dzau +1 more
TL;DR: The data suggest that BAEC is capable of synthesizing and secreting angiotensins and may play an important paracrine or autocrine role in influencing local vascular tone.
Journal ArticleDOI
Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice.
TL;DR: High level human renin expression was evident in the kidney, adrenal gland, ovary, testis, lung, and adipose tissue of all four transgenic lines examined and treatment of transgenic mice with captopril resulted in an increase in the accumulation of renal renin mRNAs derived from both the mouse andhuman renin genes.
References
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Journal ArticleDOI
A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies.
TL;DR: The avidin-biotin-peroxidase complex method successfully demonstrates polypeptide hormones even when antibodies are diluted 20 to 40 times, and produces a superior staining sensitivity.
Journal ArticleDOI
Concentrations of angiotensin-converting enzyme in tissues of the rat
D.W. Cushman,H.S. Cheung +1 more
TL;DR: High specific activities of converting enzyme were found in lung and in segments of the digestive tract, but the highest activities were in testis and epididymis, associated with tubular fluids, but not in sperm cells.
Journal ArticleDOI
Iso-renin of extrarenal origin: The tissue angiotensinogenase systems
TL;DR: Results indicating a biologic role of the angiotensinogenase system in brain, adrenal gland, uterus and tissue culture are discussed and it is suggested that these enzymes be called angiotENSinogenases.
Journal ArticleDOI
Inactive renin in human plasma
Frans H.M. Derkx,G. J. Wenting,A. J. Man In 'T Veld,Jeanette M.G. van Gool,R. P. Verhoeven,M. A. D. H. Schalekamp +5 more
TL;DR: The results indicate that so-called inactive renin is indeed physiologically related to active renin and suggest that inactive ren in can be activated not only in vitro, but also in vivo.