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Impact of mitral valve annuloplasty on mortality risk in patients with mitral regurgitation and left ventricular systolic dysfunction

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TLDR
There is no clearly demonstrable mortality benefit conferred by MVA for significant MR with severe LV dysfunction, and a prospective randomized control trial is warranted for further study of mortality with MVA in this population.
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This article is published in Journal of the American College of Cardiology.The article was published on 2005-02-01 and is currently open access. It has received 637 citations till now. The article focuses on the topics: Mitral valve annuloplasty & Mitral regurgitation.

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Effect of Mitral Valve Surgery in Patients With Dilated Cardiomyopathy and Severe Functional Mitral Regurgitation.

TL;DR: Surgery for severe FMR provides better long-term outcomes in patients with DCM, and multivariate Cox regression analysis using clinical data revealed that MV surgery and diabetes mellitus were independent predictors of clinical outcomes after adjusting for age and sex.
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Left Ventricular Stroke Work Index Associated With Outcome After Mitral Valve Surgery for Functional Regurgitation in Nonischemic Dilated Cardiomyopathy

TL;DR: T thorough hemodynamic investigations prior to surgery could provide useful indications regarding mitral valve surgery in patients with advanced non-ischemic dilated cardiomyopathy and functional mitral regurgitation, contributing to an improvement in their clinical outcomes.
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Long-Term Results of Left Ventricular Reconstructive Surgery in Patients With Ischemic Dilated Cardiomyopathy : A Multicenter Study

TL;DR: LVR can be performed with a low operative mortality and provide satisfactory long-term survival by restoring the dilated left ventricle and improving systolic function, and these improvements were still significant in the late period.
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Reasons for Screen Failure for Transcatheter Mitral Valve Repair and Replacement

TL;DR: In this paper, the authors analyzed the rates that patients with mitral regurgitation were excluded from transcatheter mitral valve therapies and reasons why, and found that the primary reason for exclusion was clinical in 38.5%, issues related to patient preference of care delivery in 38, anatomical in 13.7%, and futility in 9.0%.
References
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Journal ArticleDOI

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

TL;DR: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
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Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.

TL;DR: In patients with a prior myocardial infarction and advanced left ventricular dysfunction, prophylactic implantation of a defibrillator improves survival and should be considered as a recommended therapy.
Journal ArticleDOI

Modern Applied Statistics with S-Plus.

W. N. Venables, +1 more
- 01 Dec 1996 - 
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