Impact of mitral valve annuloplasty on mortality risk in patients with mitral regurgitation and left ventricular systolic dysfunction
Audrey H. Wu,Keith D. Aaronson,Steven F. Bolling,Francis D. Pagani,Kathy Welch,Todd M. Koelling +5 more
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TLDR
There is no clearly demonstrable mortality benefit conferred by MVA for significant MR with severe LV dysfunction, and a prospective randomized control trial is warranted for further study of mortality with MVA in this population.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2005-02-01 and is currently open access. It has received 637 citations till now. The article focuses on the topics: Mitral valve annuloplasty & Mitral regurgitation.read more
Citations
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Journal ArticleDOI
Why Do Mitral Valve Repairs Fail
TL;DR: It is demonstrated that continued adverse left ventricular (LV) remodeling may not be a prerequisite for recurrent mitral valve regurgitation in patients who had undergone initially successful repairs, demonstrating an advance in the understanding of ischemicMitral valve repair.
Journal ArticleDOI
Prognostic Significance of Right Ventricular Dysfunction in Patients With Functional Mitral Regurgitation Undergoing MitraClip.
TL;DR: The present study's results suggest that RVD is associated with worse survival of functional MR and LV dysfunction in patients undergoing MC in association with no response to N-terminal pro-B-type natriuretic peptide.
Book ChapterDOI
Stable Ischemic Heart Disease
TL;DR: The term IHD encompasses a spectrum of manifestations that vary from asymptomatic/silent myocardial ischemia to stable (chronic) angina pectoris, as well as more acute manifestations that include Prinzmetal (variant) angINA, unstable angina (UA), non-ST-segment elevationMyocardial infarction (NSTEMI), and ST-se segment elevation myocardIAL infarctions (STEMI).
Journal ArticleDOI
The Evolution of Percutaneous Mitral Valve Repair Therapy: Lessons Learned and Implications for Patient Selection
TL;DR: Percutaneous repair of the mitral valve with a particular device has emerged as a novel therapeutic option for patients with secondary MR or those deemed to be high risk for surgery, and lessons learned regarding adequate patient selection are focused.
Journal ArticleDOI
Intraoperative transesophageal echocardiography using a quantitative dynamic loading test for the evaluation of ischemic mitral regurgitation.
Avinoam Shiran,Amnon Merdler,Ehab Ismir,Rony Ammar,Amnon Y. Zlotnick,Dan Aravot,Horia Lazarovici,Eli Zisman,Reuven Pizov,Basil S. Lewis +9 more
TL;DR: A quantitative loading test with fluids and phenylephrine is useful to avoid underestimation of ischemic MR by intraoperative transesophageal echocardiography, and may detect significant MR in some patients who had unloaded LVs and nonsignificant MR during their preoperative assessment.
References
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The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
TL;DR: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
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Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.
Arthur J. Moss,Wojciech Zareba,W. Jackson Hall,Helmut U. Klein,David J. Wilber,David S. Cannom,James P. Daubert,Steven L. Higgins,Mary W. Brown,Mark L. Andrews +9 more
TL;DR: In patients with a prior myocardial infarction and advanced left ventricular dysfunction, prophylactic implantation of a defibrillator improves survival and should be considered as a recommended therapy.
Journal ArticleDOI
Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.
Michael R. Bristow,Leslie A. Saxon,John P. Boehmer,Steven K. Krueger,David A. Kass,Teresa De Marco,Peter E. Carson,Lorenzo DiCarlo,David L. DeMets,Bill G. White,Dale W DeVries,Arthur M. Feldman +11 more
TL;DR: In this paper, the authors tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation with a pacemaker with or without a defibrillator would reduce the risk of death and hospitalization among patients with advanced chronic heart failure and intraventricular conduction delays.
Journal ArticleDOI
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more