Journal ArticleDOI
Impaired interhemispheric integration in brain oxygenation and hemodynamics in schizophrenia
TLDR
Patients with chronic schizophrenia are examined to find and qualify disturbances in interhemispheric integration in brain oxygen metabolism and hemodynamics during a psychological task and certain schizophrenic symptoms may be related to defective interhemisphere integration.Abstract:
We examined 38 patients with chronic schizophrenia to find and qualify disturbances in interhemispheric integration in brain oxygen metabolism and hemodynamics during a psychological task. A group of thirty-eight age- and sex-matched healthy volunteers were monitored as controls. Multi channel near-infrared (NIR) spectrophotometry was used to observed real-time alterations in cerebral oxygenation in areas of both hemispheres of the forebrain adjacent to the forehead during the mirror drawing task (MDT). In response to MDT normal volunteers showed distinct and well-integrated patterns of changes in oxygenated hemoglobin Hb, deoxygenated Hb, and blood volume total Hb. On the other hand, half the schizophrenics showed dysregulated patterns between hemispheres which never appeared in normal volunteers. Certain schizophrenic symptoms may be related to defective interhemispheric integration.read more
Citations
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A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application.
TL;DR: A brief historical overview of the events that have shaped the present status of fNIRS is presented, including the introduction of the commercial multi-channel systems, recent commercial wireless instrumentation and more advanced prototypes.
Journal ArticleDOI
HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain.
TL;DR: The practical implementation of various signal processing techniques for removing physiological, instrumental, and motion-artifact noise from optical data are described within the context of the MATLAB-based graphical user interface program, HomER, which is developed and distributed to facilitate the processing of optical functional brain data.
Journal ArticleDOI
Non-invasive neuroimaging using near-infrared light
TL;DR: It is found that, while diffuse optics can provide substantial advantages to the psychiatric researcher relative to the alternative brain imaging methods, the method remains substantially underutilized in this field.
Journal ArticleDOI
Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy.
TL;DR: Advances currently being made and issues to consider for improving optical image quality include the optimal selection of wavelengths to minimize random and systematic error propagation in the calculation of the hemoglobin concentrations.
Journal ArticleDOI
Multichannel near-infrared spectroscopy in depression and schizophrenia: cognitive brain activation study.
TL;DR: The characteristic time courses of [oxyHb] changes in the frontal lobe were elucidated for depression and schizophrenia and near-infrared spectroscopy, with its noninvasiveness and high time resolution, can be a useful tool for research and clinical purposes in psychiatry.
References
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Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters
TL;DR: Observations by infrared transillumination in the exposed heart and in the brain in cephalo without surgical intervention show that oxygen sufficiency for cytochrome a,a3, function, changes in tissue blood volume, and the average hemoglobin-oxyhemoglobin equilibrium can be recorded effectively and in continuous fashion for research and clinical purposes.
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Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation.
TL;DR: The cytochrome aa3 spectrum in vivo from the brains of rats after replacing the blood with a fluorocarbon substitute is obtained and an algorithm for calculating the changes in oxygenated and deoxygenated haemoglobin and oxygenated cy tochrome a a3 in tissue from changes in near IR absorption is constructed.
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Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectrophotometry.
TL;DR: NIR spectrophotometry provides valuable quantitative data at the cotside for the management of sick infants and for exploring the pathophysiology of damage to the brain.