Impaired learning in mice with abnormal short-lived plasticity
Alcino J. Silva,Thomas W. Rosahl,Paul F. Chapman,Zachary Marowitz,Eugenia Friedman,Paul W. Frankland,Vincenzo Cestari,Dianna Cioffi,Thomas C. Südhof,Roussoudan Bourtchuladze +9 more
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TLDR
The results are consistent with models that propose a role for SLP in learning, as mice with decreased PPF or PTP, in the absence of known LTP deficits, also show profound learning impairments.About:
This article is published in Current Biology.The article was published on 1996-11-01 and is currently open access. It has received 188 citations till now. The article focuses on the topics: Synapsin I & Ca2+/calmodulin-dependent protein kinase.read more
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Short-Term Synaptic Plasticity
Robert S. Zucker,Wade G. Regehr +1 more
TL;DR: The evidence for this hypothesis, and the origins of the different kinetic phases of synaptic enhancement, as well as the interpretation of statistical changes in transmitter release and roles played by other factors such as alterations in presynaptic Ca(2+) influx or postsynaptic levels of [Ca(2+)]i are discussed.
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Synaptic plasticity and memory: an evaluation of the hypothesis
TL;DR: It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.
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Long-Term Potentiation and Memory
TL;DR: Lynch et al. as mentioned in this paper identified the cellular and molecu... cellular and memory cells in neuroscience is one of the most significant challenges in neuroscience and identified the most important genes for long-term potentiation and memory.
Journal ArticleDOI
Calcium- and activity-dependent synaptic plasticity.
TL;DR: High-resolution measurements of [Ca2+]i in dendritic spines show how Ca2+ can encode the precise relative timing of presynaptic input and postsynaptic activity and generate long-term synaptic modifications of opposite polarity.
Journal ArticleDOI
Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor
Neil Collinson,Frederick M. Kuenzi,Wolfgang Jarolimek,Karen A. Maubach,Rosa Cothliff,Cyrille Sur,Alison J. Smith,Franklin Otu,Owain W. Howell,John R. Atack,Ruth M. McKernan,Guy R. Seabrook,G. R. Dawson,Paul J. Whiting,Thomas W. Rosahl +14 more
TL;DR: Data suggest that α5-containing GABAA receptors play a key role in cognitive processes by controlling a component of synaptic transmission in the CA1 region of the hippocampus.
References
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Journal ArticleDOI
Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
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Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning
R. G. Phillips,Joseph E. LeDoux +1 more
TL;DR: An associative roles for the amygdala and a sensory relay role for the hippocampus are suggested in fear conditioning, which is involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli.
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Spatial Localization Does Not Require the Presence of Local Cues
TL;DR: It is demonstrated that rats can rapidly learn to locate an object that they can never see, hear, or smell provided it remains in a fixed spatial location relative to distal room cues.
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Modality-specific retrograde amnesia of fear.
TL;DR: The results indicate that fear memory is not a single process and that the hippocampus may have a time-limited role in associative fear memories evoked by polymodal (contextual) but not unimodal (tone) sensory stimuli.
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Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.