Journal ArticleDOI
Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center.
Christopher J. Dente,Beth H. Shaz,Jeffery M. Nicholas,Robert S. Harris,Amy D. Wyrzykowski,Snehal G. Patel,Amit J. Shah,Gary Vercruysse,David V. Feliciano,Grace S. Rozycki,Jeffrey P. Salomone,Walter L. Ingram +11 more
Reads0
Chats0
TLDR
In the civilian setting, aggressive use of FFP and platelets drastically reduces 24-hour mortality and early coagulopathy in patients with trauma and reduction in 30 day mortality was only seen after blunt trauma in this small subset of patients.Abstract:
Introduction:Transfusion practices across the country are changing with aggressive use of plasma (fresh-frozen plasma [FFP]) and platelets during massive transfusion with current military recommendations to use component therapy at a 1:1:1 ratio of packed red blood cells to FFP to platelets.Methods:read more
Citations
More filters
Journal ArticleDOI
The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition
Rolf Rossaint,Bertil Bouillon,Vladimir Cerny,Timothy J Coats,Jacques Duranteau,Enrique Fernández-Mondéjar,Daniela Filipescu,Beverley J. Hunt,Radko Komadina,Giuseppe Nardi,Edmund Neugebauer,Yves Ozier,Louis Riddez,Arthur Schultz,Jean Louis Vincent,Donat R. Spahn +15 more
TL;DR: The guideline now recommends that patients be transferred directly to an appropriate trauma treatment centre and encourages use of a restricted volume replacement strategy during initial resuscitation, and may also serve as a basis for local implementation.
Journal ArticleDOI
Management of severe perioperative bleeding Guidelines from the European Society of Anaesthesiology
Sibylle A. Kozek-Langenecker,Arash Afshari,Pierre Albaladejo,Cesar Aldecoa Alvarez Santullano,Edoardo De Robertis,Daniela Filipescu,Dietmar Fries,Thorsten Haas,Georgina Imberger,Matthias Jacob,Marcus D. Lancé,Juan V. Llau,Susan Mallett,Jens Meier,Niels Rahe-Meyer,Charles Marc Samama,Andrew Smith,Cristina Solomon,Philippe Van der Linden,Anne Wikkelsø,Patrick Wouters,Piet Wyffels +21 more
TL;DR: These guidelines are intended to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthetists throughout Europe to integrate this knowledge into daily patient care wherever possible.
Journal ArticleDOI
Management of bleeding and coagulopathy following major trauma: an updated European guideline
Donat R. Spahn,Bertil Bouillon,Vladimir Cerny,Timothy J Coats,Jacques Duranteau,Enrique Fernández-Mondéjar,Daniela Filipescu,Beverley J. Hunt,Radko Komadina,Giuseppe Nardi,Edmund Neugebauer,Yves Ozier,Louis Riddez,Arthur Schultz,Jean Louis Vincent,Rolf Rossaint +15 more
TL;DR: Key changes encompassed in this version of the guideline include new recommendations on the appropriate use of vasopressors and inotropic agents, and reflect an awareness of the growing number of patients in the population at large treated with antiplatelet agents and/or oral anticoagulants.
This Provisional PDF corresponds to the article as it appeared upon acceptance. Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon. Management of bleeding and coagulopathy following major trauma: an updated European guideline
Donat R. Spahn,Bertil Bouillon,Timothy J Coats,Jacques Duranteau,Enrique Fernández-Mondéjar,Daniela Filipescu,Beverley J. Hunt,Giuseppe Nardi,Edmund Neugebauer,Louis Riddez,Arthur Schultz,Jean Louis Vincent +11 more
TL;DR: In this article, the authors presented an updated version of the guideline published by the Task Force for Advanced Bleeding Care in Trauma and updated in 2010, which included new recommendations on the appropriate use of vasopressors and inotropic agents.
Journal ArticleDOI
Advanced trauma life support (ATLS®): the ninth edition.
TL;DR: The ninth edition of the ATLS course continues to emphasize one safe way to care for the trauma patient during initial assessment; it is not meant to incorporate the most advanced, cutting edge information or technology.
References
More filters
Journal ArticleDOI
'Damage control': an approach for improved survival in exsanguinating penetrating abdominal injury.
Michael F. Rotondo,C. W. Schwab,McGonigal,Phillips Gr rd,Fruchterman Tm,Donald R. Kauder,Latenser Ba,P. A. Angood +7 more
TL;DR: It is concluded that damage control is a promising approach for increased survival in exsanguinating patients with major vascular and multiple visceral penetrating abdominal injuries.
Journal ArticleDOI
The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital
Matthew A. Borgman,Philip C. Spinella,Jeremy G. Perkins,Kurt W. Grathwohl,Thomas Repine,Alec C. Beekley,James A. Sebesta,Donald H. Jenkins,Charles E. Wade,John B. Holcomb +9 more
TL;DR: In patients with combat-related trauma requiring massive transfusion, a high 1:1.4 plasma to RBC ratio is independently associated with improved survival to hospital discharge, primarily by decreasing death from hemorrhage.
Journal ArticleDOI
Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations.
TL;DR: Improvements in early hemorrhage control and resuscitation and the prevention and aggressive treatment of coagulopathy appear to have the greatest potential to improve outcomes in severely injured trauma patients.
Journal ArticleDOI
Practice guidelines for blood component therapy: A report by the American Society of Anesthesiologists Task Force on Blood Component Therapy
Linda C. Stehling,Dennis C. Doherty,Ronald J. Faust,A. Gerson Greenburg,Chantal R. Harrison,Dennis F. Landers,Russell K. Laros,Ellison C. Pierce,Randall S. Prust,Andrew D. Rosenberg,Richard B. Weiskopf,Steven H. Woolf,John F. Zeiger +12 more
TL;DR: The principal conclusions of the task force are that red blood cell transfusions should not be dictated by a single hemoglobin "trigger" but instead should be based on the patient's risks of developing complications of inadequate oxygenation.
Journal ArticleDOI
Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
Karim Brohi,Mitchell J. Cohen,Michael T. Ganter,Michael A. Matthay,Robert C. Mackersie,Jean-Francois Pittet +5 more
TL;DR: Early traumatic coagulopathy occurs only in the presence of tissue hypoperfusion and appears to occur without significant consumption of coagulation factors, which is consistent with activated protein C activation and systemic anticoagulation.
Related Papers (5)
Damage control resuscitation: Directly addressing the early coagulopathy of trauma
John B. Holcomb,Donald H. Jenkins,Peter Rhee,Jay A. Johannigman,Peter F. Mahoney,Sumeru G. Mehta,E. Darrin Cox,Michael J. Gehrke,Gregory J. Beilman,Martin A. Schreiber,Stephen F. Flaherty,Kurt W. Grathwohl,Phillip C. Spinella,Jeremy G. Perkins,Alec C. Beekley,Neil R. McMullin,Myung S. Park,Ernest A. Gonzalez,Charles E. Wade,Michael A. Dubick,C. William Schwab,Frederick A. Moore,Howard R. Champion,David B. Hoyt,John R. Hess +24 more