Journal ArticleDOI
Increase of Kv3.1b expression in avian auditory brainstem neurons correlates with synaptogenesis in vivo and in vitro.
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TLDR
During development both high and low threshold potassium currents need to be increased in a concerted manner with the sodium conductance for the neurons to exhibit fast and phasic action potential firing and a narrow time window of coincidence detection.About:
This article is published in Brain Research.The article was published on 2009-11-20. It has received 10 citations till now. The article focuses on the topics: Synaptogenesis & Neuron.read more
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Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance
Leonard K. Kaczmarek,Yalan Zhang +1 more
TL;DR: How the protein-protein interaction of these channels with other proteins affects neuronal functions, and how mutations or abnormal regulation of Kv3 channels are associated with neurological disorders such as ataxias, epilepsies, schizophrenia, and Alzheimer's disease are covered.
Journal ArticleDOI
Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.
Sabien van Neerven,Tommy Regen,Dhana Wolf,Andrei Nemes,Sonja Johann,Cordian Beyer,Uwe-Karsten Hanisch,Jörg Mey +7 more
TL;DR: In this paper, the physiologically occurring isomer, all-trans RA, affects chemokine expression by astrocytes, and the results suggest that retinoids should be further investigated as candidates for the treatment of neuroinflammation.
Journal ArticleDOI
Brain Expression of Kv3 Subunits During Development, Adulthood and Aging and in a Murine Model of Alzheimer's Disease
TL;DR: During postnatal development, K v3 transcripts and proteins showed a progressive increase in expression and reached an asymptote in adulthood, suggesting that the increase in Kv3 expression during development might contribute to the maturation of the electrical activity of neurons.
Journal ArticleDOI
Encephalopathies with KCNC1 variants: genotype-phenotype-functional correlations.
Jillian M. Cameron,Snezana Maljevic,Umesh Nair,Ye Htet Aung,Benjamin Cogné,Stéphane Bézieau,Edward Blair,Bertrand Isidor,Christiane Zweier,André Reis,Mary Kay Koenig,Timothy James Maarup,Dean Sarco,Alexandra Afenjar,A.H.M. Mahbubul Huq,Mary K. Kukolich,Thierry Billette de Villemeur,Caroline Nava,Bénédicte Héron,Steven Petrou,Samuel F. Berkovic +20 more
TL;DR: To analyze clinical phenotypes associated with KCNC1 variants other than the Progressive Myoclonus Epilepsy‐causing variant p.Arg320His, the electrophysiological functional impact of identified variants is determined and genotype‐phenotype‐physiological correlations are explored.
Journal ArticleDOI
In vivo matching of postsynaptic excitability with spontaneous synaptic inputs during formation of the rat calyx of Held synapse.
TL;DR: In this paper, the authors measured the intrinsic postsynaptic excitability of the principal neuron and the size of its largest synaptic inputs in the medial nucleus of the trapezoid body of anaesthetized rats of postnatal day (P)2-6.
References
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Journal Article
Past: paleontological statistical software package for education and data analysis
TL;DR: PAST (PAleontological STatistics) as discussed by the authors is a simple-to-use software package for executing a range of standard numerical analysis and operations used in quantitative paleontology.
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A series of normal stages in the development of the chick embryo
TL;DR: The preparation of a series of normal stages of the chick embryo does not need justification at a time when chick ernbryos are not only widely used in descriptive and experimental embryology but are proving to be increasingly valuable in medical research, as in work on viruses and cancer.
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The NEURON simulation environment
TL;DR: This work presents the basic ideas that would help informed users make the most efficient use of NEURON, the powerful and flexible environment for implementing models of individual neurons and small networks of neurons.
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A neuronal learning rule for sub-millisecond temporal coding
Wulfram Gerstner,Wulfram Gerstner,Richard Kempter,J. Leo van Hemmen,Hermann Wagner,Hermann Wagner +5 more
TL;DR: A modelling study based on computer simulations of a neuron in the laminar nucleus of the barn owl shows that the necessary degree of coherence in the signal arrival times can be attained during ontogenetic development by virtue of an unsupervised hebbian learning rule.