Journal ArticleDOI
The NEURON simulation environment
TLDR
This work presents the basic ideas that would help informed users make the most efficient use of NEURON, the powerful and flexible environment for implementing models of individual neurons and small networks of neurons.Abstract:
The moment-to-moment processing of information by the nervous system involves the propagation and interaction of electrical and chemical signals that are distributed in space and time. Biologically realistic modeling is needed to test hypotheses about the mechanisms that govern these signals and how nervous system function emerges from the operation of these mechanisms. The NEURON simulation program provides a powerful and flexible environment for implementing such models of individual neurons and small networks of neurons. It is particularly useful when membrane potential is nonuniform and membrane currents are complex. We present the basic ideas that would help informed users make the most efficient use of NEURON.read more
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Book
Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems
Peter Dayan,L. F. Abbott +1 more
TL;DR: This text introduces the basic mathematical and computational methods of theoretical neuroscience and presents applications in a variety of areas including vision, sensory-motor integration, development, learning, and memory.
Journal ArticleDOI
Reconstruction and Simulation of Neocortical Microcircuitry
Henry Markram,Henry Markram,Eilif Muller,Srikanth Ramaswamy,Michael W. Reimann,Marwan Abdellah,Carlos Aguado Sanchez,Anastasia Ailamaki,Lidia Alonso-Nanclares,Lidia Alonso-Nanclares,Nicolas Antille,Selim Arsever,Guy Antoine Atenekeng Kahou,Thomas K. Berger,Ahmet Bilgili,Nenad Buncic,Athanassia Chalimourda,Giuseppe Chindemi,Jean Denis Courcol,Fabien Delalondre,Vincent Delattre,Shaul Druckmann,Shaul Druckmann,Raphael Dumusc,James Dynes,Stefan Eilemann,Eyal Gal,Michael Gevaert,Jean Pierre Ghobril,Albert Gidon,Joe W. Graham,Anirudh Gupta,Valentin Haenel,Etay Hay,Thomas Heinis,Thomas Heinis,Juan Hernando,Michael L. Hines,Lida Kanari,Daniel Keller,John Kenyon,Georges Khazen,Yihwa Kim,James G. King,Zoltán F. Kisvárday,Pramod Kumbhar,Sebastien Lasserre,Jean Vincent Le Bé,Bruno R. C. Magalhães,Angel Merchán-Pérez,Angel Merchán-Pérez,Julie Meystre,Benjamin Roy Morrice,Jeffrey Muller,Alberto Muñoz-Céspedes,Alberto Muñoz-Céspedes,Shruti Muralidhar,Keerthan Muthurasa,Daniel Nachbaur,Taylor Howard Newton,Max Nolte,Aleksandr Ovcharenko,Juan Palacios,Luis Pastor,Rodrigo Perin,Rajnish Ranjan,Rajnish Ranjan,Imad Riachi,José-Rodrigo Rodríguez,José-Rodrigo Rodríguez,Juan Luis Riquelme,Christian Rössert,Konstantinos Sfyrakis,Ying Shi,Ying Shi,Julian C. Shillcock,Gilad Silberberg,Ricardo Silva,Farhan Tauheed,Martin Telefont,Maria Toledo-Rodriguez,Thomas Tränkler,Werner Van Geit,Jafet Villafranca Diaz,Richard Walker,Yun Wang,Yun Wang,Stefano M. Zaninetta,Javier DeFelipe,Javier DeFelipe,Sean Hill,Idan Segev,Felix Schürmann +92 more
TL;DR: A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms.
Journal ArticleDOI
Adaptive Exponential Integrate-and-Fire Model as an Effective Description of Neuronal Activity
Romain Brette,Wulfram Gerstner +1 more
TL;DR: The authors' simple model predicts correctly the timing of 96% of the spikes of the detailed model in response to injection of noisy synaptic conductances and has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.
Journal ArticleDOI
The high-conductance state of neocortical neurons in vivo.
TL;DR: Results from different approaches in understanding the integrative properties of neocortical neurons in the intact brain are summarized to help understand the complex interplay between the active properties of dendrites and how they convey discrete synaptic inputs to the soma.
Journal ArticleDOI
Mechanisms of Spreading Depression and Hypoxic Spreading Depression-Like Depolarization
TL;DR: The characteristics of spreading depression and the related hypoxic SD-like depolarization and the main hypotheses that have been proposed to explain them are reviewed.
References
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A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.
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Core Conductor Theory and Cable Properties of Neurons
TL;DR: The sections in this article are: Core Conductor Concept, Assumptions and Derivation of Cable Theory, Cable Equation Terms, and Additional Comments and References.
Related Papers (5)
A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more