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Increased circulating cytokines inpatients with myocarditis andcardiomyopathy
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TLDR
In this paper, the potential role of cytokines in the pathogenesis of cardiomyopathy and myocarditis was elucidated, and experimental studies showed that certain cytokines depress myocardialAbstract:
Objectives-To elucidate thepotential roleofcytokines inthepathogenesis of cardiomyopathy andmyocarditis. Background-Experimental studies show thatcertain cytokines depress myocardialread more
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Regulation of urocortin I and its related peptide urocortin II by inflammatory and oxidative stresses in HL-1 cardiomyocytes.
Keiichi Ikeda,Katsuyoshi Tojo,Yuri Inada,Yuko Takada,Masaya Sakamoto,May Lam,William C. Claycomb,Naoko Tajima +7 more
TL;DR: The Ucn-CRH receptor system may be regulated by two major forms of cardiac stresses, i.e. oxidative and inflammatory stress, and may play a critical role in cardiac stress adaptation in heart diseases.
Journal ArticleDOI
Expressional patterns of cytokines in a murine model of acute myocarditis: early expression of cardiotrophin-1.
Masahiko Okuno,Masao Nakagawa,Morimi Shimada,Mikiyoshi Saito,Shigemichi Hishinuma,Keiko Yamauchi-Takihara +5 more
TL;DR: CT-1 expression preceded TNF-α and IL-1α expressions and active DNA synthesis in a murine model of acute myocarditis and may exert a protective role by modulating cytokine production and by inducing cardiomyocytic proliferation in CVB3-infected murine hearts.
Journal ArticleDOI
Beneficial effects of olmesartan, an angiotensin II receptor type 1 antagonist, in rats with dilated cardiomyopathy
Vijayakumar Sukumaran,Kenichi Watanabe,Punniyakoti T. Veeraveedu,Punniyakoti T. Veeraveedu,Rajarajan Amirthalingam Thandavarayan,Narasimman Gurusamy,Meilei Ma,Ken'ichi Yamaguchi,Kenji Suzuki,Makoto Kodama,Yoshifusa Aizawa +10 more
TL;DR: It is demonstrated that olmesartan treatment significantly improved LV function and ameliorated the progression of cardiac remodeling in rats with DCM after EAM, a rat model in which myosin-induced experimental autoimmune myocarditis might develop into DCM.
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Anti-inflammatory therapy for heart failure
TL;DR: Accumulating evidence shows that heart failure is an inflammatory disease, and anti-inflammatory therapy by various agents would be a promising future treatment for heart failure.
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Clinical and neurohormonal correlates of circulating granulocyte-macrophage colony-stimulating factor in severe heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
John Parissis,Stamatis Adamopoulos,Koula F Venetsanou,Dimitrios G. Mentzikof,Spilios M Karas,Dimitrios Th. Kremastinos +5 more
TL;DR: It is shown for the first time that granulocyte-macrophage colony-stimulating factor plasma levels are elevated in patients with severe heart failure, and these levels are correlated well with neurohormonal activation and hemodynamic deterioration characterizing this syndrome.
References
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Journal ArticleDOI
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
TL;DR: It is indicated that circulating levels of tumor necrosis factor are increased in cachectic patients with chronic heart failure and that this elevation is associated with the marked activation of the renin-angiotensin system seen in patients with end-stage cardiac disease.
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Negative inotropic effects of cytokines on the heart mediated by nitric oxide
Mitchell S. Finkel,Carmine V. Oddis,Timothy D. Jacob,Simon C. Watkins,Brack G. Hattler,Richard L. Simmons +5 more
TL;DR: The findings demonstrate that the direct negative inotropic effect of cytokines is mediated through a myocardial nitric oxide synthase, and the regulation of pro-inflammatory cytokines and myocardia nitricoxide synthase may provide new therapeutic strategies for the treatment of cardiac disease.
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A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation
Anja A.T. Geisterfer-Lowrance,Susan Kass,Gary Tanigawa,Hans-Peter Vosberg,William J. McKenna,Christine E. Seidman,Jon G. Seidman +6 more
TL;DR: Identification of two unique mutations within cardiac MHC genes in all individuals with FHC from two unrelated families demonstrates that defects in the cardiac M HC genes can cause this disease.
Journal Article
Myocarditis. A histopathologic definition and classification.
HT Aretz,ME Billingham,William D. Edwards,SM Factor,John T. Fallon,Jr Jj Fenoglio,E. G. J. Olsen,Frederick J. Schoen +7 more
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Characteristics and Prognostic Implications of Myosin Missense Mutations in Familial Hypertrophic Cardiomyopathy
Hugh Watkins,Anthony Rosenzweig,Dar-San Hwang,Tatjana Levi,William J. McKenna,Christine E. Seidman,Jonathan G. Seidman +6 more
TL;DR: It is suggested that the precise definition of the disease-causing mutation can provide important prognostic information about affected members in families with hypertrophic cardiomyopathy.