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Increased circulating cytokines inpatients with myocarditis andcardiomyopathy
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TLDR
In this paper, the potential role of cytokines in the pathogenesis of cardiomyopathy and myocarditis was elucidated, and experimental studies showed that certain cytokines depress myocardialAbstract:
Objectives-To elucidate thepotential roleofcytokines inthepathogenesis of cardiomyopathy andmyocarditis. Background-Experimental studies show thatcertain cytokines depress myocardialread more
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Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α
Debora D. Bryant,Lisa Becker,James A. Richardson,John M. Shelton,Fátima Franco,Ronald M Peshock,Marita Thompson,Brett P. Giroir +7 more
TL;DR: It is indicated that production of TNF-alpha by cardiac myocytes is sufficient to cause severe cardiac disease and support a causal role for this cytokine in the pathogenesis of human cardiac disease.
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Inflammatory mediators in chronic heart failure: an overview
TL;DR: The purpose of this review is to give a brief overview of the current understanding of the role of inflammation in CHF, and to discuss recent advances in the development of new therapeutic strategies in this field.
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Myocarditis: Current Trends in Diagnosis and Treatment
Jared W. Magnani,G. William Dec +1 more
TL;DR: Clinical practice guidelines with regard to its evaluation and treatment are lacking because the wide variety of etiologies implicated in myocarditis and its heterogeneous clinical presentations have impeded patient identification and consensus on the most appropriate diagnostic criteria.
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Viral Persistence in the Myocardium Is Associated With Progressive Cardiac Dysfunction
Uwe Kühl,Matthias Pauschinger,Bettina Seeberg,Dirk Lassner,Michel Noutsias,Wolfgang Poller,Heinz-Peter Schultheiss +6 more
TL;DR: In this first biopsy-based analysis of the course of viral heart disease, it is shown that EV, ADV, PVB19, and HHV6 persistence detected in the myocardium of patients with LV dysfunction was associated with a progressive impairment of LVEF, whereas spontaneous viral elimination wasassociated with a significant improvement in LV function.
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From Myocarditis to Cardiomyopathy: Mechanisms of Inflammation and Cell Death Learning From the Past for the Future
TL;DR: The rather discouraging results obtained to date with immunosuppressive agents in the treatment of viral myocarditis indicated the importance of sparing neutralizing antibody production, which may be controlled by B cells, and raised the possibility of promising developments in immunomodulating therapy.
References
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Journal ArticleDOI
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
TL;DR: It is indicated that circulating levels of tumor necrosis factor are increased in cachectic patients with chronic heart failure and that this elevation is associated with the marked activation of the renin-angiotensin system seen in patients with end-stage cardiac disease.
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Negative inotropic effects of cytokines on the heart mediated by nitric oxide
Mitchell S. Finkel,Carmine V. Oddis,Timothy D. Jacob,Simon C. Watkins,Brack G. Hattler,Richard L. Simmons +5 more
TL;DR: The findings demonstrate that the direct negative inotropic effect of cytokines is mediated through a myocardial nitric oxide synthase, and the regulation of pro-inflammatory cytokines and myocardia nitricoxide synthase may provide new therapeutic strategies for the treatment of cardiac disease.
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A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation
Anja A.T. Geisterfer-Lowrance,Susan Kass,Gary Tanigawa,Hans-Peter Vosberg,William J. McKenna,Christine E. Seidman,Jon G. Seidman +6 more
TL;DR: Identification of two unique mutations within cardiac MHC genes in all individuals with FHC from two unrelated families demonstrates that defects in the cardiac M HC genes can cause this disease.
Journal Article
Myocarditis. A histopathologic definition and classification.
HT Aretz,ME Billingham,William D. Edwards,SM Factor,John T. Fallon,Jr Jj Fenoglio,E. G. J. Olsen,Frederick J. Schoen +7 more
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Characteristics and Prognostic Implications of Myosin Missense Mutations in Familial Hypertrophic Cardiomyopathy
Hugh Watkins,Anthony Rosenzweig,Dar-San Hwang,Tatjana Levi,William J. McKenna,Christine E. Seidman,Jonathan G. Seidman +6 more
TL;DR: It is suggested that the precise definition of the disease-causing mutation can provide important prognostic information about affected members in families with hypertrophic cardiomyopathy.