Open Access
Increased circulating cytokines inpatients with myocarditis andcardiomyopathy
Reads0
Chats0
TLDR
In this paper, the potential role of cytokines in the pathogenesis of cardiomyopathy and myocarditis was elucidated, and experimental studies showed that certain cytokines depress myocardialAbstract:
Objectives-To elucidate thepotential roleofcytokines inthepathogenesis of cardiomyopathy andmyocarditis. Background-Experimental studies show thatcertain cytokines depress myocardialread more
Citations
More filters
Journal ArticleDOI
Persistent Expression of Cytokines inÈthe Chronic Stage of CVB3-induced Myocarditis in NMRI Mice
TL;DR: Data indicate that the persistence of viral RNA is associated with persistently high levels of cytokine mRNAs which, when translated, could severely contribute to pathological changes and injury of connective tissue in the chronic stage of myocarditis.
Journal ArticleDOI
TNF-α increases cardiac fibroblast lysyl oxidase expression through TGF-β and PI3Kinase signaling pathways.
TL;DR: The results indicate that TNF-α stimulated LOX expression may play an important role in progressive cardiac fibrosis, and inhibition of TGF-β receptor I or Smad3 prevented increased LOXexpression by TNFs.
Journal ArticleDOI
Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.
TL;DR: Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI‐3 kinase pathways may be a newly discovered mechanism that regulates these events in association with cy toprotective effect in myocardial diseases.
Journal ArticleDOI
Adenosine and cardioprotection in the diseased heart.
Masafumi Kitakaze,Tetsuo Minamino,Koichi Node,Seiji Takashima,Hiroharu Funaya,Tsunehiko Kuzuya,Masatsugu Hori +6 more
TL;DR: In this article, the authors found that ecto-5'-nucleotidase activation activated the enzyme responsible for adenosine release, which may act as an endogenous cardioprotective substance in pathophysiological conditions of the heart.
Journal ArticleDOI
Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease
Guadalupe Hernández-Pacheco,Carmina Flores-Dominguez,José Manuel Rodríguez-Pérez,Nonanzit Pérez-Hernández,José Manuel Fragoso,Angela Saul,Edith Alvarez-León,Julio Granados,Pedro A. Reyes,Gilberto Vargas-Alarcón +9 more
TL;DR: The data demonstrate that RHD is associated with TNF-alpha polymorphisms in the Mexican population; however, these polymorphisms do not have relation with the valve damage.
References
More filters
Journal ArticleDOI
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
TL;DR: It is indicated that circulating levels of tumor necrosis factor are increased in cachectic patients with chronic heart failure and that this elevation is associated with the marked activation of the renin-angiotensin system seen in patients with end-stage cardiac disease.
Journal ArticleDOI
Negative inotropic effects of cytokines on the heart mediated by nitric oxide
Mitchell S. Finkel,Carmine V. Oddis,Timothy D. Jacob,Simon C. Watkins,Brack G. Hattler,Richard L. Simmons +5 more
TL;DR: The findings demonstrate that the direct negative inotropic effect of cytokines is mediated through a myocardial nitric oxide synthase, and the regulation of pro-inflammatory cytokines and myocardia nitricoxide synthase may provide new therapeutic strategies for the treatment of cardiac disease.
Journal ArticleDOI
A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation
Anja A.T. Geisterfer-Lowrance,Susan Kass,Gary Tanigawa,Hans-Peter Vosberg,William J. McKenna,Christine E. Seidman,Jon G. Seidman +6 more
TL;DR: Identification of two unique mutations within cardiac MHC genes in all individuals with FHC from two unrelated families demonstrates that defects in the cardiac M HC genes can cause this disease.
Journal Article
Myocarditis. A histopathologic definition and classification.
HT Aretz,ME Billingham,William D. Edwards,SM Factor,John T. Fallon,Jr Jj Fenoglio,E. G. J. Olsen,Frederick J. Schoen +7 more
Journal ArticleDOI
Characteristics and Prognostic Implications of Myosin Missense Mutations in Familial Hypertrophic Cardiomyopathy
Hugh Watkins,Anthony Rosenzweig,Dar-San Hwang,Tatjana Levi,William J. McKenna,Christine E. Seidman,Jonathan G. Seidman +6 more
TL;DR: It is suggested that the precise definition of the disease-causing mutation can provide important prognostic information about affected members in families with hypertrophic cardiomyopathy.