Increased Levels of Soluble ST2 in Patients with Active Newly Diagnosed ANCA-Associated Vasculitis
Z. Hladinova,Zdenka Hruskova,B. Svobodova,Karin Malickova,V. Lanska,P. Konopasek,Eva Jancova,Romana Rysava,Charles L. Edelstein,Vladimir Tesar +9 more
TLDR
Serum sST2, but not serum IL-33, may be a marker of activity in AAV patients, and these levels were higher in patients with granulomatosis with polyangiitis than in patients in remission.Abstract:
Objective. ST2, a member of the interleukin-1 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. IL-33 is a specific ligand of ST2. The aim of the study was to determine whether serum levels of soluble ST2 (sST2) or IL-33 predict activity of the disease in patients with ANCA-associated vasculitides (AAV). Methods. 139 AAV patients and 62 controls were studied. IL-33 and sST2 in the blood were measured with a commercially available ELISA. Results. Newly diagnosed AAV patients had higher sST2 levels than controls (P < 0.01). Levels of sST2 were significantly higher in active newly diagnosed AAV patients than in patients with remission (P < 0.001). IL-33 levels were higher in AAV patients than in the control groups (P = 0.002). However, serum IL-33 levels were not increased in patients with active AAV compared to patients in remission. IL-33 levels were higher in patients with granulomatosis with polyangiitis than in patients with microscopic polyangiitis (P = 0.012). Conclusions. Serum sST2, but not serum IL-33, may be a marker of activity in AAV patients.read more
Citations
More filters
Journal ArticleDOI
Immunopathogenesis of ANCA-Associated Vasculitis.
Andreas Kronbichler,Keum Hwa Lee,Sara Denicolò,Daeun Choi,Hyo Jeong Lee,Donghyun Ahn,Kang Hyun Kim,Ji Han Lee,Hyung Tae Kim,Minha Hwang,Sun Wook Jung,Changjun Lee,Hojune Lee,Haejune Sung,Dongkyu Lee,Jaehyuk Hwang,Sohee Kim,Injae Hwang,Do Young Kim,Hyungjun Kim,Geonjae Cho,Yunryoung Cho,Dong-Il Kim,Min Je Choi,Junhye Park,Junseong Park,Kalthoum Tizaoui,Han Li,Lee Smith,Ai Koyanagi,Louis Jacob,Philipp Gauckler,Jae Il Shin +32 more
TL;DR: The current understanding of the immunopathogenesis of ANCA-associated vasculitis and the interplay between ANCA serotype and proposed disease biomarkers are summarized and it is illustrated how the extending knowledge of the Immunopathogenesis will likely translate into development of a personalized medicine approach in the management of AN CA-associated Vasculitis.
Journal ArticleDOI
Innate immune response reflects disease activity in eosinophilic granulomatosis with polyangiitis
Naomi Tsurikisawa,Chiyako Oshikata,Maiko Watanabe,Takahiro Tsuburai,Takeshi Kaneko,Hiroshi Saito +5 more
TL;DR: Interleukin (IL)‐33, thymic stromal lymphopoietin (TSLP), and type 2 innate lymphoid cells (ILC2) are involved in the innate and type 1 immune responses in EGPA.
Journal ArticleDOI
Increased Soluble Suppression of Tumorigenicity 2 Level Predicts All-Cause and Cardiovascular Mortality in Maintenance Hemodialysis Patients: A Prospective Cohort Study
Zhen Zhang,Bo Shen,Xuesen Cao,Zhonghua Liu,Xiaohong Chen,Yuxin Nie,Jinbo Yu,Jianzhou Zou,Xiaoqiang Ding +8 more
TL;DR: The prognostic value of sST2 was additive to N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT), as the combined use of s ST2 and NT- ProBNP or hs-c TnT better identified higher-risk patients.
Journal ArticleDOI
Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis.
Liya Li,Honglin Zhu,Xiaoxia Zuo +2 more
TL;DR: This work reviews the available information and focuses on the pleiotropic expression and pathogenesis of IL-33 in systemic sclerosis, as well as the feasibility of using IL- 33 in clinical applications.
Journal ArticleDOI
IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer.
Kameswaran Ravichandran,Sara J. Holditch,Carolyn N. Brown,Qian Wang,Abdullah Ozkok,Mary C.M. Weiser-Evans,Raphael A. Nemenoff,Makoto Miyazaki,Heather Thiessen-Philbrook,Chirag R. Parikh,Danica Galešić Ljubanović,Charles L. Edelstein +11 more
TL;DR: The data that IL-33 deficiency does not protect against AKI in a clinically relevant model suggest thatIL-33 inhibition may not be useful to attenuateAKI in patients with cancer, however, serum IL- 33 may serve as a biomarker of AKI.
References
More filters
Book
Cellular and Molecular Immunology
TL;DR: Cellular and molecular immunology , Cellular and molecular Immunology , کتابخانه الکرونیک و دیجیتال - آذرسا
Journal ArticleDOI
Small-Vessel Vasculitis
TL;DR: Protean clinical manifestations, combined with the etiologic nonspecificity of the histologic lesions, complicate the diagnosis of specific forms of vasculitis.
Journal ArticleDOI
Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies
Richard A. Watts,SE Lane,Thomas Hanslik,Thomas H. Hauser,Bernhard Hellmich,Wenche Koldingsnes,Alfred Mahr,Mårten Segelmark,Jan Willem Cohen-Tervaert,David Scott +9 more
TL;DR: A stepwise algorithm developed by consensus between a group of doctors interested in the epidemiology of vasculitis successfully categorises patients into a single classification of patients with Wegener’s granulomatosis, microscopic polyangiitis, Churg–Strauss syndrome and PAN into single clinically relevant categories.
Journal ArticleDOI
IL‐1, IL‐18, and IL‐33 families of cytokines
TL;DR: The interleukin‐1 (IL‐1), IL‐18, and IL‐33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized.
Journal ArticleDOI
The IL-33/ST2 pathway: therapeutic target and novel biomarker
Rahul Kakkar,Richard T. Lee +1 more
TL;DR: It is shown that a novel mechanism of intramyocardial fibroblast–cardiomyocyte communication that may prove to be a therapeutic target for the prevention of heart failure is discovered.