Journal ArticleDOI
Increased liver chemiluminescence in tumor-bearing mice.
TLDR
The liver of tumor-bearing animals is subjected, during the early phase after tumor implantation, to an oxidative stress with increased steady-state levels of peroxyl radicals, which are essentially responsible for the increased photoemission observed in vivo.About:
This article is published in Journal of Free Radicals in Biology & Medicine.The article was published on 1985-01-01. It has received 49 citations till now.read more
Citations
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Journal Article
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Journal ArticleDOI
Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle.
TL;DR: Liver and heart homogenates were subjected to in vitro oxidative stresses such as supplementation with organic hydroperoxide or with enzymatic systems generating superoxide anion or hydrogen peroxide and chemiluminescence was higher in the poststress samples than in the control ones.
Book ChapterDOI
Free Radical Scavenging and Antioxidant Activity of Plant Flavonoids
TL;DR: Their increased production seems to accompany most forms of tissue injury, and the formation of free radicals has been implicated in a multitude of disease states ranging from inflammatory/immune injury to myocardial infarction and cancer.
Journal ArticleDOI
Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence.
TL;DR: The in vitro and in vivo effects of these flavonoids and polyphenols may be related to their antioxidant abilities, making them promising substances to be investigated as water-soluble protectors against lipid peroxidation and other free radical-mediated cell injury.
Journal ArticleDOI
Oxidative stress by acute acetaminophen administration in mouse liver.
TL;DR: The results indicate the occurrence of oxidative stress as a possible mechanism for acetaminophen-induced hepatotoxicity, and the activities of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase were determined.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
Journal ArticleDOI
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
TL;DR: The use of the foregoing analytical method in the determination of total and oxidized glutathione contents of rat blood, kidney, and liver gave values in good agreement with those obtained by previous investigators.
Journal ArticleDOI
Hydroperoxide metabolism in mammalian organs.
Journal ArticleDOI
The cellular production of hydrogen peroxide
TL;DR: The cytochrome c peroxidase assay is suitable for use with subcellular fractions from tissue homogenates as well as with pure enzyme systems to measure H(2)O( 2) generation and can be made on the basis of the rates with the isolated fractions under physiological conditions.