Infection and inflammation and the coagulation system
TLDR
The relevance of the cross-talk between inflammation and coagulation is underlined by the promising results in the treatment of severe systemic infection with modulators of coagulations and inflammation.Abstract:
Severe infection and inflammation almost invariably lead to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation (DIC). Systemic inflammation results in activation of coagulation, due to tissue factor-mediated thrombin generation, downregulation of physiological anticoagulant mechanisms, and inhibition of fibrinolysis. Pro-inflammatory cytokines play a central role in the differential effects on the coagulation and fibrinolysis pathways. Vice-versa, activation of the coagulation system may importantly affect inflammatory responses by direct and indirect mechanisms. Apart from the general coagulation response to inflammation associated with severe infection, specific infections may cause distinct features, such as hemorrhagic fever or thrombotic microangiopathy. The relevance of the cross-talk between inflammation and coagulation is underlined by the promising results in the treatment of severe systemic infection with modulators of coagulation and inflammation.read more
Citations
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Journal ArticleDOI
Inflammation and coagulation.
Marcel Levi,Tom van der Poll +1 more
TL;DR: It is shown that activation of the coagulation system and ensuing thrombin generation is dependent on expression of tissue factor and the simultaneous down-regulation of endothelial-bound anticoagulant mechanisms and endogenous fibrinolysis, and activated coagulations may affect specific cellular receptors on inflammatory cells and endothelial cells and thereby modulate the inflammatory response.
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Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study
TL;DR: The incidence of venous thromboembolism (VTE) is increased in cancer, but little information is available about risk factors in cancer patients on chemotherapy.
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Thromboembolism in Hospitalized Neutropenic Cancer Patients
Alok A. Khorana,Charles W. Francis,Eva Culakova,Richard I. Fisher,Nicole M. Kuderer,Gary H. Lyman +5 more
TL;DR: In this article, the authors investigated venous and arterial thromboembolism and associated outcomes in hospitalized cancer patients actively receiving therapy, as identified by neutropenia.
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The interaction of bacterial pathogens with platelets.
TL;DR: The nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases are reviewed.
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Mechanisms of sepsis-induced organ dysfunction
Edward Abraham,Mervyn Singer +1 more
TL;DR: Applying systems approaches to these complex processes will permit better appreciation of the effectiveness or harm of treatments, both present and future, and also will allow development not only of better directed, but also of more appropriately timed, strategies to improve outcomes from this still highly lethal condition.
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