Journal ArticleDOI
Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study
Alexandre Persu,W Vinck,Ouarda El Khattabi,Rob G J H Janssen,Aimee D C Paulussen,Olivier Devuyst,Robert Vlietinck,Robert Fagard +7 more
TLDR
The results pave the way for studies looking for the influence of NOS3 on blood pressure in high-risk subsets such as diabetic or hypertensive patients, and indicate the importance of ambulatory blood pressure and haplotype analysis in revealing the moderate effect of polymorphisms onBlood pressure.Abstract:
BACKGROUND: Nitric oxide is involved in the regulation of vascular basal tone and blood pressure. Polymorphisms of NOS3, the gene that codes for endothelial nitric oxide synthase, have been associated with essential hypertension. OBJECTIVE: To look for linkage and association of three di-allelic polymorphisms (Glu298Asp, intron 4 VNTR and T-786C) and the intron 13 CA-repeat of NOS3 with blood pressure as a continuous trait. METHODS: Genotyping was performed in 110 dizygotic white twin pairs from Flanders, Belgium. The influence of NOS3 polymorphisms on conventional and ambulatory blood pressure was assessed by sib-pair analysis and haplotype association analysis. RESULTS: Genotype frequencies were similar to those previously reported in white populations. Sib-pair analysis did not show a significant influence of either polymorphism on blood pressure. Haplotype analysis disclosed a significant association between NOS3 haplotypes and daytime ambulatory diastolic (P = 0.02) and systolic (P < 0.0001) blood pressure, the latter remaining significant after multiple testing was taken into account (P = 0.032). The association between daytime ambulatory systolic blood pressure and NOS3 haplotypes was mainly attributable to four haplotypes accounting for 11.9% of all represented haplotypes. CONCLUSION: We show for the first time a highly significant association of ambulatory blood pressure with NOS3 haplotypes in well-characterized white individuals from Flanders. These results pave the way for studies looking for the influence of NOS3 on blood pressure in high-risk subsets such as diabetic or hypertensive patients. They indicate the importance of ambulatory blood pressure and haplotype analysis in revealing the moderate effect of polymorphisms on blood pressure.read more
Citations
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Journal ArticleDOI
Endothelial nitric oxide synthase haplotypes affect the susceptibility to hypertension in patients with type 2 diabetes mellitus.
Valeria C. Sandrim,Roger W.C. de Syllos,Hugo Roberto Kurtz Lisboa,Glaucia Sarturi Tres,Jose E. Tanus-Santos +4 more
TL;DR: A protective effect for eNOS haplotypes "C Glu b" against the development of hypertension, and that haplotype "C Asp b" increases the susceptibility to hypertension in patients without or with T2DM are suggested.
Journal ArticleDOI
Targeting reactive oxygen species in hypertension.
TL;DR: In clinical practice, diagnostic procedures beyond measurement of blood pressure will be necessary to predict the response to antioxidants; these procedures will include measurement of antioxidant status and detailed assessment of vascular structure and function.
Journal ArticleDOI
Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy.
Valeria C. Sandrim,Juan Carlos Yugar-Toledo,Zeruesenay Desta,David A. Flockhart,Heitor Moreno,Jose E. Tanus-Santos +5 more
TL;DR: The results suggest that eNOS haplotypes are not associated with resistance to antihypertensive therapy and suggest a protective effect for the ‘C Glu b’ haplotype against hypertension.
Journal ArticleDOI
Genetic variation in the KCNMA1 potassium channel α subunit as risk factor for severe essential hypertension and myocardial infarction
Marta Tomás,Esther Vázquez,José M. Fernández-Fernández,Isaac Subirana,Cristina Plata,Magda Heras,Joan Vila,Jaume Marrugat,Miguel A. Valverde,Mariano Sentí +9 more
TL;DR: Genetic evidence is provided that highlights the relevance of the Ca2+-dependent potassium channel in the control of human blood pressure and its impact on cardiovascular disease.
Journal ArticleDOI
Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study.
TL;DR: Blood pressure progression and incident hypertension are not consistently associated with six well-characterized genetic polymorphisms of the renin–angiotensin system and the NOS3 gene in a large cohort of Caucasian women.
References
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Journal ArticleDOI
Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Journal ArticleDOI
Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous
TL;DR: New methods of testing the statistical association between haplotypes and a wide variety of traits, including binary, ordinal, and quantitative traits are developed, which allow adjustment for nongenetic covariates, which may be critical when analyzing genetically complex traits.
Journal ArticleDOI
Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man.
TL;DR: Results indicate that the dilator action of endothelium-derived NO contributes to the control of basal and stimulated regional blood flow in man.
European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure
Roland Asmar,Lawrie J. Beilin,Yutaka Imai,Jean-Michel Mallion,Giuseppe Mancia,Thomas Mengden,Martin G. Myers,Paul L. Padfield,Paolo Palatini,Gianfranco Parati,Thomas G. Pickering,Josep Redon,Jan A. Staessen,George S. Stergiou,Paolo Verdecchia +14 more
TL;DR: The accuracy of the conventional Riva-Rocci/Korotkoff technique of blood pressure measurement has been questioned and efforts have been made to improve the technique with automated devices.
Journal ArticleDOI
European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement.
Eoin O'Brien,Roland Asmar,Lawrie J. Beilin,Yutaka Imai,Jean-Michel Mallion,Giuseppe Mancia,Thomas Mengden,Martin G. Myers,Paul L. Padfield,Paolo Palatini,Gianfranco Parati,Thomas G. Pickering,Josep Redon,Jan A. Staessen,George S. Stergiou,Paolo Verdecchia +15 more
TL;DR: In this paper, the accuracy of the conventional Riva-Rocci/Korotkoff technique of blood pressure measurement has been questioned and efforts have been made to improve the technique with automated devices.
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