Inhibition of aminopropyltransferases by S-adenosylmethionine: Effect of simultaneous administration of S-adenosylmethionine and methylglyoxal bis(guanylhydrazone) on polyamine concentrations in regenerating rat liver
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TLDR
It is demonstrated that partially purified aminopropyltr~sfera~s from rat liver were strongly inhibited by SAM and that administration of SAM in combination with methylglyoxal bis(guanylhydrazone) (MGBG) caused a decrease in the concentration of spermid~e, which may be useful for understanding the regulation of polyamine synthesis in eukaryotic cells.About:
This article is published in FEBS Letters.The article was published on 1980-02-11 and is currently open access. It has received 5 citations till now. The article focuses on the topics: Mitoguazone & Methylglyoxal.read more
Citations
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Journal ArticleDOI
Role of Polyamines in the Control of Cell Proliferation and Differentiation
Book ChapterDOI
Polyamines in mammalian tumors. Part I.
TL;DR: This chapter investigates the links between polyamines and tumors by modifying the culture conditions to clarify the influence of the environmental milieu on the activities of the polyamine biosynthetic enzymes by enhancing or decreasing the levels of these enzymes to see the role of polyamines in the cell growth process.
Journal ArticleDOI
Dicyclohexylamine, a potent inhibitor of spermidine synthase in mammalian cells
TL;DR: It is demonstrated that partially purified spermidine synthase from rat ventral prostate was strongly inhibited by dicyclohexylamine and also by cycloheoxylamine, and that administration of dicyCloheXYlamine caused a decrease in the concentration of sperMidine but not spermine in the liver of partially hepatectomized rats.
Journal ArticleDOI
Effect of methionine deprivation on S-adenosylmethionine decarboxylase of tumour cells
TL;DR: Transference of Walker carcinoma and TLX5 lymphoma from normal L-methionine-containing medium to medium containing limiting amounts of L-homocysteine only, caused a 2-fold increase of S-adenosylmeth ionine decarboxylase activity, which appears to be mainly due to enhanced stabilization.
Book ChapterDOI
Methionine Metabolism in the Brain
TL;DR: A review of the metabolism of methionine in the central nervous system as seen by a group of us who worked together on this problem for over a decade and follow the pathway of sulfur metabolism only as far as cyst(e)ine.
References
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Journal ArticleDOI
1,4-Diaminobutane (Putrescine), Spermidine, and Spermine
C W Tabor,H Tabor +1 more
TL;DR: No specific mechanism has been firmly established for the action of the polyamines in vivo, however, it is clear that these compounds are physiologically important, and further work is necessary to establish the mechanism of their action.
Journal ArticleDOI
Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases.
TL;DR: The putrescine-activated S-adenosylmethionine decarboxylases of rat ventral prostate and baker's yeast are strongly inhibited by methyl glyoxal bis(guanylhydrazone), a substance which has been reported to exhibit anti-leukemic actions.
Journal ArticleDOI
Polyamines in mammalian biology and medicine
TL;DR: Three aliphatic amines of widespread biological occurrence whose molecular structures were established over 50 years ago are studied.
Related Papers (5)
S-adenosylmethionine metabolism and its relation to polyamine synthesis in rat liver. Effect of nutritional state, adrenal function, some drugs and partial hepatectomy.
Terho O. Eloranta,Aarne Raina +1 more