Journal ArticleDOI
Inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur-containing compounds.
Andrea L. Hunter,Robert A. Neal +1 more
TLDR
Thiono-sulfur-containing compounds administered by intraperitoneal injection to untreated, phenobarbital-pretreated and 3-methylcholanthrene-pret treated adult male rats significantly decreased the concentration of cytochrome P-450 in the microsomes from each treatment group, and similar reductions in benzphetamine metabolism were seen.About:
This article is published in Biochemical Pharmacology.The article was published on 1975-12-01. It has received 173 citations till now. The article focuses on the topics: Benzphetamine & Microsome.read more
Citations
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Journal ArticleDOI
Suicide substrates: mechanism-based enzyme inactivators
TL;DR: Suicide substrates are defined as a class of irreversible inactivators of specific target enzymes where the target enzyme participates in its own destruction by catalytic unmasking of a latent functional group at some stage in the catalytic cycle of the enzyme.
Journal ArticleDOI
Inhibitors of Cytochrome P-450s and their mechanism of action.
Bernard Testa,Peter Jenner +1 more
TL;DR: Drug Metabolism Reviews: Vol.
Book ChapterDOI
Inhibitors of chemical carcinogenesis.
TL;DR: A number of compounds that have the capacity to inhibit the neoplastic effects of chemical carcinogens when administered either prior to exposure to the carcinogen or at the same time are described.
Journal ArticleDOI
Antimutagenicity profiles for some model compounds
TL;DR: Activity profiles are useful for the assessment of the available antimutagenesis data by providing rapid visualization of considerable dose information and experimental results.
Book ChapterDOI
Nutrition and its relationship to cancer
TL;DR: This chapter presents an evaluation of the status of the relationship between nutrition and cancer in man, discusses the use of animal models to determine if the etiological factors established for man can be modified in an experimental setting, and makes recommendations for additional research and possible preventive measures.
References
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Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal Article
Biochemical and pharmacological changes in the rat following chronic administration of morphine, nalorphine and normorphine
Joseph Cochin,Julius Axelrod +1 more
TL;DR: The N-demethylating enzyme is proposed as a model for the study of narcotic-drug receptor sites and the degree of tolerance, cross-tolerance and depression of enzymatic activity depends on the amount of drug given per day rather than on the duration of drug administration.
Journal ArticleDOI
Kinetic parameters of drug-metabolizing enzymes in Ca2+-sedimented microsomes from rat liver☆
TL;DR: Kinetic parameters of five substrates of the mixedfunction oxidase system were determined to ensure that the mixed function oxidases were unaltered by the Ca 2+ -sedimented microsomes.
Journal ArticleDOI
Liver Tumors in Rats Fed Thiourea or Thioacetamide.
TL;DR: Thiourea administered orally to albino rats for a prolonged period of time induces liver tumors, without liver cirrhosis, in a large percentage of cases at concentrations which may be below those producing hyperplasia of the thyroid gland.
Related Papers (5)
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more