Journal ArticleDOI
Inhibitors of Cytochrome P-450s and their mechanism of action.
Bernard Testa,Peter Jenner +1 more
TLDR
Drug Metabolism Reviews: Vol.Abstract:
(1981). Inhibitors of Cytochrome P-450s and Their Mechanism of Action. Drug Metabolism Reviews: Vol. 12, No. 1, pp. 1-117.read more
Citations
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Journal ArticleDOI
Enzymic mechanisms of superoxide production.
Andrew R. Cross,Owen T.G. Jones +1 more
TL;DR: The known biological sources of superoxide, the enzymic machinery used to generate it, and the possible functions to which it is put are described.
Journal ArticleDOI
Inhibition and induction of human cytochrome P450 (CYP) enzymes.
Journal ArticleDOI
Renal cytochrome P450-related arachidonate metabolite inhibits (Na + + K + )ATPase
TL;DR: In cells derived primarily from the mTALH of the outer medulla of rabbit kidney, a cytochrome P450-dependent monooxygenase system is identified which metabolizes arachidonic acid to two biologically active oxygenated products; one of the products inhibits (Na+ + K+)ATPase and the other relaxes blood vessels.
Book ChapterDOI
Biochemical Targets for Antifungal Azole Derivatives: Hypothesis on the Mode of Action
TL;DR: An amazing number of antifungal agents are found within the group of azole-containing compounds, and they show excellent activity against phytopathogenic fungi.
Book ChapterDOI
Inhibition of Cytochrome P450 Enzymes
TL;DR: Cytochrome P450s (P450s) are subject to inhibition/inactivation by various chemically diverse agents, which may interact directly or indirectly with either the P450 prosthetic heme or the protein moiety or with both moieties.
References
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Journal Article
Acetaminophen-induced hepatic necrosis. i. role of drug metabolism
TL;DR: It is proposed thatacetaminophen-induced hepatic necrosis is mediated by a toxic metabolite of acetaminophen, which inhibits synthesis of cytochrome P-450 and thereby prevented the hepatic damage.
Journal ArticleDOI
Factors affecting drug metabolism.
TL;DR: It has become increasingly evident that most of the oxidative reactions are catalyzed by enzyme systems in liver endoplasmic reticulum, which is disrupted by homogenization to form microsomes, and the diversity of the reactions catalyzing by these enzymes is virtually unique in biochemistry.
Journal ArticleDOI
Cimetidine: interaction with oral anticoagulants in man
M.J. Serlin,S Mossman,R.G. Sibeon,Alasdair Breckenridge,J.R.B. Williams,J.L. Atwood,J.M.T. Willoughby +6 more
TL;DR: In 6 patients anticoagulated with warfarin, nicoumalone, or phenindione the addition of cimetidine prolonged the prothrombin-time (PT) by a mean of 12.6 s (range 5--23 s), and in 7 volunteers taking daily subtherapeutic doses ofwarfarin the added cimetamine increased the PT.
Journal Article
Characteristics of a microsomal cytochrome P-448-mediated reaction. Ethoxyresorufin O-de-ethylation.
TL;DR: The results support previous suggestions that the reaction is catalyzed primarily by a 3-methyl-cholanthrene (MC)-inducible mono-oxygenase which has a 448-nm absorption maximum in the reduced-CO difference spectrum.
Journal ArticleDOI
Nature of O2 and CO binding to metalloporphyrins and heme proteins.
TL;DR: The O2 vibration of dioxygen adducts of Fe and Co model complexes of alpha,alpha, alpha, alpha-tetrapivalamidophenylporphyrin ("picket fence" porphyrin, TpivPP) with 1-methylimidrazole and 1-tritylimidazole as axial bases are reported.
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The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more