Inhibition of protein denaturation by fatty acids, bile salts and other natural substances: a new hypothesis for the mechanism of action of fish oil in rheumatic diseases.
Luciano Saso,Giovanni Valentini,Maria Luisa Casini,Eleonora Mattei,L. Braghiroli,Gabriela Mazzanti,Claudio Panzironi,Eleonora Grippa,Bruno Silvestrini +8 more
TLDR
It is speculated that the antidenaturant activity of fish oil may be partly (in addition to the known effect on endogenous eicosanoid composition) responsible for its beneficial effects in rheumatoid arthritis and other rheumatic conditions.About:
This article is published in Japanese Journal of Pharmacology.The article was published on 1999-01-01 and is currently open access. It has received 37 citations till now. The article focuses on the topics: Fatty acid & Docosahexaenoic acid.read more
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Inhibition of heat-induced denaturation of albumin by nonsteroidal antiinflammatory drugs (NSAIDs): Pharmacological implications
Luciano Saso,Giovanni Valentini,Maria Luisa Casini,Eleonora Grippa,Maria Teresa Gatto,Maria Grazia Leone,Bruno Silvestrini +6 more
TL;DR: A survey of nonsteroidal antiinflammatory drugs in rheumatoid arthritis found that NSAIDs were slightly less active than FA and that the HPLC method was capable of distinguishing true antiaggregant agents like FA and NSAIDs from substances capable of inhibiting the precipitation of denatured protein aggregates.
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Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis.
TL;DR: Results showed that the majority of nutraceuticals studied possess beneficial effect toward chronic inflammatory diseases, which might be due to the presence of one or more of the above-mentioned phytochemicals.
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Human serum albumin binding ibuprofen: a 3D description of the unfolding pathway in urea.
TL;DR: Small angle X-ray scattering (SAXS) technique allowed us to restore the 3D structure at low resolution of defatted human serum albumin (HSA) in interaction with ibuprofen, representing a type of analysis which could be exploited in future investigations on proteins in solution, in the binding of drugs or endogenous compounds and in the pharmacokinetic properties
Journal Article
Evaluation of anti-gout activity of some plant food extracts.
Doha A. Mohamed,Sahar Y. Al-Okbi +1 more
TL;DR: In this article, the anti-gout activity of methanol and petroleum ether extracts of celery leaves, celery seeds, rosemary, cinnamon and turmeric as functional food components was studied in potassium oxonate treated rats.
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In vitro anti-denaturation and anti-hyaluronidase activities of extracts and galactolipids from leaves of Impatiens parviflora DC
Karolina Grabowska,Irma Podolak,Agnieszka Galanty,Daniel Załuski,Justyna Makowska-Wąs,Danuta Sobolewska,Zbigniew Janeczko,Paweł Żmudzki +7 more
TL;DR: Results indicate that fresh leaves of I. parviflora may be beneficial in inflammatory conditions, especially those associated with protein denaturation, such as rheumatoid arthritis, and the potential of galactolipids in the treatment of diseases associated with the loss of hyaluronic acid.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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Removal of Fatty Acids from Serum Albumin by Charcoal Treatment
TL;DR: Fluorescence spectra of human serum albumin samples indicated that impurities are sometimes present which can be removed by charcoal at neutral pH, and acid-charcoal treatment is a much more rapid method of removing lipid impurities than other methods previously described.
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Clinical trial of indomethacin in Alzheimer's disease
Joseph Rogers,L. C. Kirby,S. R. Hempelman,D. L. Berry,Patrick L. McGeer,Alfred W. Kaszniak,J. Zalinski,M. Cofield,L. Mansukhani,P. Willson,F. Kogan +10 more
TL;DR: Indomethacin appeared to protect mild to moderately impaired Alzheimer's disease patients from the degree of cognitive decline exhibited by a well-matched, placebo-treated group.
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On the conformational stability of globular proteins - the effects of various electrolytes and nonelectrolytes on the thermal ribonuclease transition
Peter H. von Hippel,K Y Wong +1 more
TL;DR: Physicochemical instrumental analysis methods used in the study include polarimetry, viscometry, ultraviolet (UV) spectroscopy, short column sedimentation (weight average molecular weights) and spectrophotometry and interferometry were used to characterize the bovine pancreatic ribonuclease.