Insights into the Management of Papillary Microcarcinoma of the Thyroid.
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TLDR
Interestingly, older patients with low-risk PMCs are the best candidates for active surveillance, and they are most unlikely to grow in older patients (≥60 years).Abstract:
Background: Rapid increases in the incidence of thyroid carcinoma with stable mortality rates from thyroid carcinoma have been reported from many countries, and these increases are thought to be due mostly to the increased detection of small papillary thyroid carcinomas (PTCs), including papillary microcarcinomas (PMCs; i.e., PTCs ≤10 mm). Some researchers have suggested that small PTCs have been overdiagnosed and overtreated. In Japan, the active surveillance of patients with low-risk PMCs was initiated by Kuma Hospital (1993) and Tokyo's Cancer Institute Hospital (1995) based on the extremely higher incidences of both latent thyroid carcinomas in autopsy studies and small PTCs detected in mass screening studies using ultrasound examinations compared to the prevalence of clinical thyroid carcinomas. Methods: The above two institutions' data are summarized regarding the active surveillance of low-risk PMCs, and future prospects for their management are discussed. Results: At 10-year observations in the Ku...read more
Citations
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Journal ArticleDOI
Performance of a Genomic Sequencing Classifier for the Preoperative Diagnosis of Cytologically Indeterminate Thyroid Nodules
Kepal N. Patel,Trevor E. Angell,Joshua E. Babiarz,Neil M. Barth,Thomas Blevins,Quan-Yang Duh,Ronald Ghossein,R. Mack Harrell,Jing Huang,Giulia C. Kennedy,Su Yeon Kim,Richard T. Kloos,Virginia A. LiVolsi,Gregory W. Randolph,Peter M. Sadow,Michael H. Shanik,Julie Ann Sosa,S. Thomas Traweek,P. Sean Walsh,Duncan Whitney,Michael W. Yeh,Paul W. Ladenson +21 more
TL;DR: Its 36% increase in specificity compared with the gene expression classifier potentially increases the number of patients with benign nodules who can safely avoid unnecessary diagnostic surgery.
Journal ArticleDOI
Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma
Iwao Sugitani,Yasuhiro Ito,Dai Takeuchi,Hirotaka Nakayama,Chie Masaki,Hisakazu Shindo,Masanori Teshima,Kazuhiko Horiguchi,Yusaku Yoshida,Toshiharu Kanai,Mitsuyoshi Hirokawa,Kiyomi Y Hames,Isao Tabei,Akira Miyauchi +13 more
TL;DR: If appropriately applied, AS of low-risk PTMC is a safe management strategy offering favorable outcomes and preserves quality of life at low cost.
Journal ArticleDOI
High Serum TSH Level Is Associated With Progression of Papillary Thyroid Microcarcinoma During Active Surveillance.
Hye In Kim,Hye Won Jang,Hyeon Seon Ahn,Soohyun Ahn,So-Young Park,Young Lyun Oh,Soo Yeon Hahn,Jung Hee Shin,Jung-Han Kim,Jee Soo Kim,Jae Hoon Chung,Tae Hyuk Kim,Sun Wook Kim +12 more
TL;DR: Sustained elevation of serum TSH levels during active surveillance is associated with PTMC progression, and maintaining a low-normal TSH range with levothyroxine treatment during active Surveillance of PTMC might be considered in future studies.
Journal ArticleDOI
Patient Experience of Thyroid Cancer Active Surveillance in Japan.
Louise Davies,Louise Davies,Louise Davies,Benjamin R. Roman,Mitsuhiro Fukushima,Yasuhiro Ito,Akira Miyauchi +6 more
TL;DR: Levels of cancer worry reported by patients under active surveillance decreased over time, and patients expressed satisfaction with their disease management decision, suggesting that the possibility of cancerorry should not be viewed as prohibitive to successful active surveillance in thyroid cancer.
Journal ArticleDOI
The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives
TL;DR: Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Shanghai, China, and Department of Hospital Pathological, College of medicine, The Catholic University of Korea, Seoul, Korea.
References
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Louise Davies,H. Gilbert Welch +1 more
TL;DR: In this article, the authors examined trends in thyroid cancer incidence, histology, size distribution, and mortality in the United States, concluding that the increasing incidence of thyroid cancer is primarily due to the increased detection of small papillary cancers.
Journal ArticleDOI
Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013.
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Journal ArticleDOI
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