Journal ArticleDOI
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ?
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TLDR
The clinical presentation of aberrant scars is reviewed and it is illustrated how they can be differentiated and how altered expression levels and the distribution of several factors may contribute to their unique clinical characteristics and presentation.Abstract:
GENERAL PURPOSE:To provide information about the clinical presentation of hypertrophic scars and keloids based on their varied structural components.TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest iread more
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Toward understanding scarless skin wound healing and pathological scarring.
Sanna-Maria Karppinen,Ritva Heljasvaara,Donald Gullberg,Kaisa Tasanen,Kaisa Tasanen,Taina Pihlajaniemi +5 more
TL;DR: The central mechanisms and processes in excessive scarring and acute wound healing, which can lead to the formation of keloids or hypertrophic scars, the two types of fibrotic scars caused by burns or other traumas resulting in significant functional or aesthetic disadvantages are summarized.
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Keloids: a review of therapeutic management
TL;DR: In this paper, the authors provide an overview of updated treatment recommendations for keloidal scar formation and discuss insight into management to assist patient-focused, evidence-based clinical decision making.
Journal Article
Keloids: A Review of Etiology, Prevention, and Treatment.
TL;DR: Despite the growing literature investigating reliable methods for keloid management, there are no standardized guidelines or treatment protocols supported by academic governing bodies and stronger evidence with high-fidelity randomized clinical trials will be needed to determine the optimal therapy regimens.
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Hypertrophic scars and keloids: Overview of the evidence and practical guide for differentiating between these abnormal scars.
TL;DR: The goal of this review was to summarize and evaluate all publications in which both hypertrophic scars and keloids were studied and compared to one another within the same study.
Journal ArticleDOI
Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases
TL;DR: Keloid disorder can serve as a model system of fibrotic diseases, a group of currently intractable disorders, and deciphering of the critical pathogenetic steps leading to ECM accumulation is expected to identify targets for pharmacologic intervention, not only for keloids but also for a number of other Fibroproliferative diseases.
References
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Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
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Interleukin-10 and the interleukin-10 receptor.
TL;DR: Findings that have advanced the understanding of IL-10 and its receptor are highlighted, as well as its in vivo function in health and disease.
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The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
TL;DR: The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway, and this review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses.
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Taking Cell-Matrix Adhesions to the Third Dimension
TL;DR: These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesion, and as such they may be more biologically relevant to living organisms.