Journal ArticleDOI
Insomnia in the Elderly: Cause, Approach, and Treatment
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TLDR
The causes of insomnia in the elderly, the approach to patient evaluation, and the nonpharmacologic and pharmacologic treatment of insomnia are reviewed.About:
This article is published in The American Journal of Medicine.The article was published on 2006-06-01. It has received 283 citations till now. The article focuses on the topics: Sleep disorder & Insomnia.read more
Citations
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Journal ArticleDOI
Melatonin decreases delirium in elderly patients: A randomized, placebo‐controlled trial
Tareef Al-Aama,Christopher Brymer,Iris Gutmanis,Sarah Woolmore-Goodwin,Jacquelin Esbaugh,Monidipa Dasgupta +5 more
TL;DR: Disturbance in the metabolism of tryptophan and tryPTophan‐derived compounds (e.g., melatonin) may have a role in the pathogenesis of delirium.
Journal ArticleDOI
Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist
Christopher J. Winrow,Anthony L. Gotter,Christopher D. Cox,Scott M. Doran,Pamela L. Tannenbaum,Michael J. Breslin,Susan L. Garson,Steven V. Fox,Charles M. Harrell,Joanne Stevens,Duane R. Reiss,Donghui Cui,Paul J. Coleman,John J. Renger +13 more
TL;DR: Dosed orally Suvorexant significantly and dose-dependently reduced locomotor activity and promoted sleep in rats, dogs, and rhesus monkeys, highlighting a unique opportunity to develop dual orexin antagonists as a novel therapy for insomnia.
Journal ArticleDOI
Review of Safety and Efficacy of Sleep Medicines in Older Adults.
Jennifer Schroeck,James H. Ford,Erin L. Conway,Kari Kurtzhalts,Megan E. Gee,Krista A. Vollmer,Kari A. Mergenhagen +6 more
TL;DR: The future direction of insomnia treatment should have an emphasis on nonpharmacologic interventions, treating comorbid conditions, and focusing therapy on using benzodiazepines and non-BzRAs as last resorts.
Journal ArticleDOI
Age-related reduction in daytime sleep propensity and nocturnal slow wave sleep.
TL;DR: The age-related decline in SWS and reduction in daytime sleep propensity may reflect a lessening in homeostatic sleep requirement and healthy older adults without sleep disorders can expect to be less sleepy during the daytime than young adults.
Journal ArticleDOI
Insomnia in Parkinson’s disease: frequency and progression over time
TL;DR: Most nocturnal sleeping problems in patients with Parkinson’s disease varied little in prevalence over time, whereas problems related to turning in bed and vivid dreaming or nightmares increased.
References
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Journal ArticleDOI
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
TL;DR: The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.
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Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.
TL;DR: In this study, 12 young, healthy, normal-weight men exhibited reductions in the satiety hormone leptin, increases in the hunger hormone ghrelin, and increases in hunger after 2 nights of only 4 hours of sleep compared with after two nights of 10 hours ofSleep, suggesting inadequate sleep seems to influence the hormones that regulate satiety and hunger.
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Sleep complaints among elderly persons: an epidemiologic study of three communities.
Daniel J. Foley,Andrew A. Monjan,Brown Sl,Eleanor M. Simonsick,Robert B. Wallace,Dan G. Blazer +5 more
TL;DR: In multivariate analyses, sleep complaints were associated with an increasing number of respiratory symptoms, physical disabilities, nonprescription medications, depressive symptoms and poorer self-perceived health.
Book
Handbook of the Biology of Aging
TL;DR: Lower Organisms: Identification of Longevity, Neurobiological Correlates of Age-Related Cognitive Decline: Animal Models, and Mechanisms Controlling in Vitro Cellular Senescene.
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Effect of sleep loss on C-Reactive protein, an inflammatory marker of cardiovascular risk ☆
Hans K. Meier-Ewert,Paul M. Ridker,Nader Rifai,Meredith M. Regan,Nicholas J. Price,David F. Dinges,Janet Mullington +6 more
TL;DR: It is proposed that sleep loss may be one of the ways that inflammatory processes are activated and contribute to the association of sleep complaints, short sleep duration, and cardiovascular morbidity observed in epidemiologic surveys.