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Showing papers in "The American Journal of Medicine in 2006"


Journal ArticleDOI
TL;DR: Increased attention to the systematic collection of validity evidence for scores from psychometric instruments will improve assessments in research, patient care, and education.

1,359 citations


Journal ArticleDOI
TL;DR: In this paper, the association between metabolic syndrome and risk of cardiovascular disease was examined. But the use of different definitions of the metabolic syndrome has led to inconsistent results on the association of metabolic syndrome with risk of heart disease.

1,098 citations


Journal ArticleDOI
TL;DR: The emergence and spread of resistance in Enterobacteriaceae are complicating the treatment of serious nosocomial infections and threatening to create species resistant to all currently available agents.

950 citations


Journal ArticleDOI
TL;DR: The findings of this prospective, population-based study suggest that higher levels of IL-6 and CRP increase the risk of muscle strength loss, whereas high levels of ACT decrease the risk in older men and women.

840 citations


Journal ArticleDOI
TL;DR: In this paper, the authors showed that insulin resistance is a product of decreased insulin-stimulated skeletal muscle glycogen synthesis, which can mostly be attributed to decreased insulin stimulated glucose transport (Glut 4) activity.

745 citations


Journal ArticleDOI
TL;DR: Mild chronic hyponatremia induces a high incidence of falls possibly as the result of marked gait and attention impairments, and treating these patients might prevent a considerable number of hospitalizations.

730 citations


Journal ArticleDOI
TL;DR: The frequency of hyponatremia occurring in special clinical conditions--including congestive heart failure, cirrhosis, pneumonia, and acquired immunodeficiency syndrome--as well as in marathon runners will be reviewed.

652 citations


Journal ArticleDOI
TL;DR: A temporal and spatial pattern of the edema episodes is examined by evaluating the long-term course of hereditary angioedema in order to establish a specific swelling pattern and allows a tentative diagnosis based on clinical symptoms and the course of the disease.

604 citations


Journal ArticleDOI
TL;DR: QoL in "general" patients with AF as well as the effects that rate and/or rhythm-control interventions have on QoL are examined, suggesting that patients with atrial fibrillation have impaired QoO, and that QOL can be significantly improved through rate or rhythm- control strategies.

536 citations


Journal ArticleDOI
TL;DR: In this article, the authors performed a multi-centre randomized, open-label clinical trial using objective outcome measures comparing long-term therapeutic tinzaparin subcutaneously once daily with usual-care longterm vitamin-K-antagonist therapy for 3 months.

508 citations


Journal ArticleDOI
TL;DR: Patients with cancer had twice the incidence of venous thromboembolism, pulmonary embolism and deep venousThrombosis as patients without cancer.

Journal ArticleDOI
TL;DR: Although the incidence of very late stent thrombosis more than 1 year after coronary revascularization is low, drug-eluting stents appear to increase the risk for late thromBosis.

Journal ArticleDOI
TL;DR: Results show a decline in invasive pneumococcal disease (IPD) since the introduction of 7-valent pneumitiscal conjugate vaccine, and suggest that, where available, vaccines may be useful in the battle to slow the spread of resistant gram-positive cocci.

Journal ArticleDOI
TL;DR: Fruit and vegetable juices may play an important role in delaying the onset of Alzheimer's disease, particularly among those who are at high risk for the disease.

Journal ArticleDOI
TL;DR: Patients with acute heart failure syndromes (AHFS) typically present with signs and symptoms of systemic and pulmonary congestion at admission but are discharged with persistent symptoms and/or minimal or no weight loss in spite of the fact that the main reason for admission was clinical congestion.

Journal ArticleDOI
TL;DR: In this large cohort, past and current cigarette smoking were related to the development of RA, in particular seropositive RA, with prolonged increased risk after cessation.

Journal ArticleDOI
TL;DR: Reports of the predictive value of minor elevation of serum C-reactive protein levels for atherosclerotic events imply a mild degree of tissue stress or injury, suggesting the hypothesis that the presence of distressed cells is commonly the stimulus for CRP production.

Journal ArticleDOI
TL;DR: Low-dose aspirin increases the risk of major bleeding by ∼70%, but the absolute increase is modest: 769 patients need to be treated with aspirin to cause one additional major bleeding episode annually.


Journal ArticleDOI
TL;DR: An important approach to reducing the rate of fractures is first to target treatments to patients at high risk for fracture and then to develop strategies to improve treatment continuation rates.

Journal ArticleDOI
TL;DR: The available evidence suggests that valerian might improve sleep quality without producing side effects, and future studies should assess a range of doses of standardized preparations of Valerian and include standard measures of sleep quality and safety.

Journal ArticleDOI
John E. McGowan1
TL;DR: Improved antibiotic stewardship and infection-control measures will be needed to prevent or slow the emergence and spread of multidrug-resistant, nonfermenting gram-negative bacilli in the healthcare setting.

Journal ArticleDOI
TL;DR: The study confirms the increase of short- and medium-term survival in patients with SLE, but long-term prognosis remains poor in Patients with severe SLE manifestations, particularly focusing on the influence of disease severity.

Journal ArticleDOI
TL;DR: The causes of insomnia in the elderly, the approach to patient evaluation, and the nonpharmacologic and pharmacologic treatment of insomnia are reviewed.

Journal ArticleDOI
TL;DR: In this paper, the authors analyzed the trends in clinical presentation over the last 52 years in a large cohort of biopsy-proven patients seen in 1 center and found that there is a trend toward fewer patients presenting with symptomatic celiac disease characterized by diarrhea and a significant shift toward more patients presenting as asymptomatic adults.

Journal ArticleDOI
TL;DR: By combining magnetic resonance imaging techniques with pharyngeal physiological assessments, this work sought to determine the structural and functional basis for the increased propensity for airway collapse among older persons.

Journal ArticleDOI
TL;DR: In this paper, the impact of varying hemoglobin levels on mortality, function, and cognition in a representative population of older persons was explored in a prospective cohort study with 1 744 men and women, aged 71 years or older, from a random household sample living in Durham and surrounding counties in North Carolina.

Journal ArticleDOI
TL;DR: DM is associated with a large increase in mortality, particularly among subjects without clinical CAD, underscoring the importance of aggressive management of DM in HF.

Journal ArticleDOI
TL;DR: Calcium results in a sustained reduction in bone loss and turnover, but its effect on fracture remains uncertain, and poor long-term compliance limits its effectiveness.

Journal ArticleDOI
TL;DR: In this sample of hypertensive patients who have good access to health care and medication benefits, African Americans continued to have lower levels of blood pressure control despite considering more than 20 factors related toBlood pressure control.