Insulin analogues and their potential in the management of diabetes mellitus.
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This article is published in Diabetologia.The article was published on 1999-10-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: Insulin aspart & Insulin glargine.read more
Citations
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Journal ArticleDOI
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.
M. Lepore,S. Pampanelli,Carmine G. Fanelli,Francesca Porcellati,L Bartocci,A. Di Vincenzo,C Cordoni,E Costa,Paolo Brunetti,Geremia B. Bolli +9 more
TL;DR: Glargine is a peakless insulin, it lasts nearly 24 h, it has lower intersubject variability than NPH and ultralente, and it closely mimics CSII, the gold standard of basal insulin replacement.
Journal ArticleDOI
Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.
Peter Kurtzhals,Lauge Schäffer,Anders Robert Sorensen,Claus Kristensen,Ib Jonassen,Christoph Schmid,Thomas Trüb +6 more
TL;DR: The combination of the B31B32diArg and A21Gly substitutions provided insulin glargine with a 6- to 8-fold increased IGF-I receptor affinity and mitogenic potency compared with human insulin, and the reduced in vitro potency of insulin detemir might explain why this analog is not as effective on a molar basis as human insulin in humans.
Journal ArticleDOI
Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.
TL;DR: Use of insulin glargine instead of NPH in insulin combination regimens in type 2 diabetes is associated with less nocturnal hypoglycemia and lower post-dinner glucose levels, consistent with peakless and longer duration of action of insulinglargine compared with NPH.
Journal ArticleDOI
Glucose Metabolism and Regulation: Beyond Insulin and Glucagon
TL;DR: This work states that new understanding of the roles of other pancreatic and incretin hormones has led to a multi-hormonal view of glucose homeostasis.
Journal ArticleDOI
Basal Insulin Therapy in Type 2 Diabetes: 28-week comparison of insulin glargine (HOE 901) and NPH insulin
TL;DR: In patients with type 2 diabetes, once-daily bedtime insulin glargine is as effective as once- or twice-daily NPH in improving and maintaining glycemic control and deonstrates a lower risk of nocturnal hypoglycemia and less weight gain compared with NPH insulin.
References
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Journal ArticleDOI
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.
Diabetes Control,David M. Nathan,Saul M. Genuth,John M. Lachin,Patricia A. Cleary,O Crofford,Matthew M. Davis,Larry Rand,Carolyn Siebert +8 more
TL;DR: Intensive therapy effectively delays the onset and slows the progression of diabetic retinopathy, nephropathy, and neuropathy in patients with IDDM.
Journal ArticleDOI
The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus.
TL;DR: Long-term intensified insulin treatment, as compared with standard treatment, retards the development of microvascular complications in patients with insulin-dependent diabetes mellitus.
Book ChapterDOI
Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by
TL;DR: The physical, chemical, and biological properties of insulin in the light of the atomic arrangement found in insulin crystals are reviewed in this paper, where the relation of the three-dimensional arrangement of the atoms in the molecule of 2-zinc insulin crystal to the solution properties of the insulin (particularly its states of aggregation), to the chemical reaction and chemical modification of the molecule, and to its primary biological activity is discussed.
Journal ArticleDOI
Monomeric insulins obtained by protein engineering and their medical implications
J. Brange,Ulla Ribel,J. F. Hansen,G. Dodson,M. T. Hansen,S. Havelund,S. G. Melberg,Fanny Norris,K. Norris,L. Snel,A.R. Sørensen,H. O. Voigt +11 more
TL;DR: It is reported that it is possible, by single amino-acid substitutions, to make insulins which are essentially monomeric at pharmaceutical concentrations and which have largely preserved their biological activity, capable of giving diabetic patients a more physiological plasma insulin profile at the time of meal consumption.
Journal ArticleDOI
[Lys(B28), Pro(B29)]-Human Insulin: A Rapidly Absorbed Analogue of Human Insulin
TL;DR: Although the addition of zinc retarded the absorption of LYSPRO slightly, it displays faster pharmacodynamic action than human Regular insulin when injected subcutaneously and retains its distinct profile.
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