Journal ArticleDOI
Intracellular analysis of a postsynaptic action of adenosine in the rat hippocampus.
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TLDR
It is suggested that AD produces both presynaptic depression of transmitter release and postsynaptic increase in K+ conductance as well as hyperpolarization and decreased EPSP.About:
This article is published in European Journal of Pharmacology.The article was published on 1982-04-23. It has received 172 citations till now. The article focuses on the topics: Hyperpolarization (biology) & Postsynaptic potential.read more
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Book ChapterDOI
The physiological role of adenosine in the central nervous system.
TL;DR: This chapter's attention is directed to the actions of adenosine and related purines in the CNS, and the receptors and biochemical actions that underlie these functional responses and behavioral responses to purinergic drugs are considered.
Journal ArticleDOI
Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors
TL;DR: Evidence is presented to suggest that adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic modulator and also as a neuromodulator at the synaptic level, which originated from different metabolic sources, and involve receptors with different sub-cellular localisation.
Journal ArticleDOI
Synaptic Control of Motoneuronal Excitability
TL;DR: A background description of motoneurons: their development, anatomical organization, and membrane properties, both passive and active, and a description of the major transmitter systems that affect mot oneuronal excitability, focusing on synaptic and cellular properties.
Journal ArticleDOI
On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins.
TL;DR: It was concluded that Ado and m-ACh receptors link with the same population of K+ channels via GTP-binding proteins Ni and/or No in the atrial cell membrane.
Journal ArticleDOI
Increased anxiogenic effects of caffeine in panic disorders
TL;DR: The results suggest that some panic disorder patients may have abnormalities in neuronal systems involving adenosine, and patients with anxiety disorders may benefit by avoiding caffeine-containing foods and beverages.
References
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Journal ArticleDOI
Characteristics of CA1 neurons recorded intracellularly in the hippocampal in vitro slice preparation.
TL;DR: Intracellular recordings were made from CA1 pyramidal cells in the hippocampal in vitro slice preparation, and apparently normal behavior of the neurons makes the isolated hippocampal slice a promising cortical preparation.
Journal ArticleDOI
ADENINE NUCLEOTIDES AND SYNAPTIC TRANSMISSION IN THE in vitro RAT HIPPOCAMPUS
Thomas V. Dunwiddie,B.J. Hoffer +1 more
TL;DR: Adenosine is not the transmitter at this CA1 pyramidal cell synapse, but is apparently present in the extracellular compartment in sufficient concentrations to affect the synaptic physiology of this region, and this provides strong evidence in favour of the concept of a neuromodulatory role for adenosine in the central nervous system.
Journal ArticleDOI
Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex
TL;DR: Intracellular recordings showed that adenosine 5'-monophosphate hyperpolarizes cerebral cortical neurons and suppresses spontaneous and evoked excitatory postsynaptic potentials in the absence of any pronounced alterations in membrane resistance or of the threshold for action potential generation.
Journal ArticleDOI
The action of serotonin in the rat hippocampal slice preparation.
TL;DR: These experiments indicate that 5‐HT produces its effects in the rat hippocampus by activating K+ channels and is true post‐synaptic responses and are not indirect effects since they are present in a Ca2‐deficient Mg2+‐enriched medium which blocks synaptic transmission.
Journal ArticleDOI
Adenosine depression of hippocampal neurons in vitro: An intracellular study of dose-dependent actions on synaptic and membrane potentials
George R. Siggins,Peter Schubert +1 more
TL;DR: In CA1 pyramidal neurons, 5 micrometer adenosine had no measurable effect on resting membrane potential or resistance, while excitatory and inhibitory postsynaptic potentials generated by orthodromic stimulation of the stratum radiatum were reduced by 20--60%.
Related Papers (5)
ADENINE NUCLEOTIDES AND SYNAPTIC TRANSMISSION IN THE in vitro RAT HIPPOCAMPUS
Thomas V. Dunwiddie,B.J. Hoffer +1 more
Adenosine regulates via two different types of receptors, the accumulation of cyclic amp in cultured brain cells
The role of adenosine and its nucleotides in central synaptic transmission.
J.W. Phillis,P.H. Wu +1 more