Journal ArticleDOI
Intracellular calcium homeostasis.
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This article is published in British Medical Bulletin.The article was published on 1986-01-01. It has received 413 citations till now. The article focuses on the topics: Calcium & Intracellular.read more
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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
TL;DR: The hypothesis that beta-amyloid can destabilize neuronal calcium regulation and render neurons more vulnerable to environmental stimuli that elevate intracellular calcium levels is tested.
Journal ArticleDOI
Magnesium. An update on physiological, clinical and analytical aspects.
TL;DR: The improved procedures for the assay of different magnesium states are useful in understanding the role of magnesium in health and disease.
Journal Article
Mechanisms of cell injury by activated oxygen species.
TL;DR: The hypothesis most consistent with all available data suggests that 02 reduces a cellular source of ferric to ferrous iron, and the latter then reacts with H202 to produce a more potent oxidizing species, like the *OH or an equivalently reactive species.
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Regulation of growth cone behavior by calcium.
Stanley B. Kater,LR Mills +1 more
TL;DR: The role of intracellular calcium in the regulation of growth cone behaviors is considered and a working hypothesis stated, “if [intracellular] calcium falls below an optimal level, or rises significantly above it, growth cone motility and neurite outgrowth are inhibited” is put forward.
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Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.
TL;DR: The identification of mice carrying PMCA mutations that lead to diseases such as hearing loss and ataxia, as well as the corresponding phenotypes of genetically engineered PMCA "knockout" mice further support the concept of specific, nonredundant roles for each Ca( 2+) pump isoform in cellular Ca(2+) regulation.