Journal ArticleDOI
Intravenous injection in man of 9 -tetrahydrocannabinol and 11-OH- 9 -tetrahydrocannabinol.
TLDR
Intravenous infusion of this preparation to humans indicates that both tetrahydrocannabinols are equally potent in producing the typical marihuana-like pschological and physiological effects.Abstract:
A microsuspension of Delta(9)-tetrahydrocannabinol and of its metabolic derivative 11-OH-Delta(9)-tetrahydrocannabinol has been prepared with 25 percent human serum albumin as the vehicle. Intravenous infusion of this preparation to humans indicates that both tetrahydrocannabinols are equally potent in producing the typical marihuana-like pschological and physiological effects.read more
Citations
More filters
Journal ArticleDOI
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Allyn C. Howlett,Francis Barth,Tom I. Bonner,Guy A. Cabral,Pierre Casellas,William A. Devane,Christian C. Felder,Miles Herkenham,Ken Mackie,Billy R. Martin,Raphael Mechoulam,Roger G. Pertwee +11 more
TL;DR: It is considered premature to rename cannabinoid receptors after an endogenous agonist as is recommended by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification, because pharmacological evidence for the existence of additional types of cannabinoid receptor is emerging and other kinds of supporting evidence are still lacking.
Journal ArticleDOI
Pharmacokinetics and Pharmacodynamics of Cannabinoids
TL;DR: Properties of cannabis that might be of therapeutic use include analgesia, muscle relaxation, immunosuppression, sedation, improvement of mood, stimulation of appetite, antiemesis, lowering of intraocular pressure, bronchodilation, neuroprotection and induction of apoptosis in cancer cells.
Journal ArticleDOI
Human Cannabinoid Pharmacokinetics
TL;DR: The cardiovascular and subjective effects of cannabis are blocked by rimonabant, the first CB-1 cannabinoid-receptor antagonist, documenting thatCB-1 receptors mediate these effects of smoked cannabis in humans.
Journal ArticleDOI
The cannabinoid receptors.
TL;DR: The biological activities, pharmacology, and signal transduction mechanisms for the cannabinoid receptors, with particular emphasis on the responses to the eicosanoid ligands are described.
References
More filters
Journal ArticleDOI
Marihuana: Studies on the Disposition and Metabolism of Delta-9-Tetrahydrocannabinol in Man
TL;DR: Δ9-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t1/2 = 56 hours); its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound.
Journal ArticleDOI
Activity of Δ8-and Δ9-Tetrahydrocannabinol and Related Compounds in the Mouse
HD Christensen,RI Freudenthal,JT Gidley,Roni Rosenfeld,G Boegli,L Testino,Dolores R. Brine,C Pitt,Monroe E. Wall +8 more
TL;DR: The 11-hydroxy metabolites of Δ8.- and Δ9-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route.
Journal ArticleDOI
Isolation, structure, and biological activity of several metabolites of delta-9-tetrahydrocannabinol
Journal ArticleDOI
The in vitro and in vivo metabolism of tetrahydrocannabinol (thc)
TL;DR: In vitro and, in some cases, in vivo studies on the metabolism of Asand A*-THC and related cannabinoids are carried out at the Research Triangle Institute.