Journal ArticleDOI
Involvement of 5-lipoxygenase metabolites in ACTH-stimulated corticosteroidogenesis in rat adrenal glands
TLDR
Results indicate that 5-LO pathway is present in rat adrenocortical cells and its metabolites, most likely 5-HPETE, may play an important role in adrenal steroidogenesis.About:
This article is published in Prostaglandins.The article was published on 1985-11-01. It has received 47 citations till now. The article focuses on the topics: Adrenal cortex & Arachidonate 5-lipoxygenase.read more
Citations
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Journal ArticleDOI
The role of arachidonic acid in steroidogenesis and steroidogenic acute regulatory (StAR) gene and protein expression.
TL;DR: It is indicated that AA and cAMP transduce signals from trophic hormone receptors to the nucleus through two separate pathways and act to co-regulate steroid production and StAR gene expression and indicates that both pathways are required for troPHic hormone-stimulated steroidogenesis.
Journal ArticleDOI
The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol triphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancretic islets
Journal ArticleDOI
Specific action of the lipoxygenase pathway in mediating angiotensin II-induced aldosterone synthesis in isolated adrenal glomerulosa cells.
TL;DR: The studies suggest that the 12-LO pathway plays a key role as a new specific mediator of AII-induced aldosterone secretion.
Journal ArticleDOI
Signal transduction involving cyclic AMP-dependent and cyclic AMP-independent mechanisms in the control of steroidogenesis.
TL;DR: It is concluded that while cAMP is a second messenger for LH/ACTH in the control of steroidogenesis, other signalling systems exist which are potentially equally effective in controlling steroidogenesis.
Journal ArticleDOI
The effect of dietary arachidonic acid on growth, survival, and cortisol levels in different-age gilthead seabream larvae (Sparus auratus) exposed to handling or daily salinity change.
William Koven,Rogier D. van Anholt,Sigal Lutzky,Isashar Ben Atia,O. Nixon,Benny Ron,A. Tandler +6 more
TL;DR: It was shown that dietary ArA promoted survival in fish encountering only handling stress, and repetitive salinity change altered the nature of the stress response where dietaryArA appeared to upregulate cortisol synthesis coinciding with reduced growth and increased mortality.
References
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Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation
TL;DR: Platelet aggregation induced by thrombin was accompanied by release of material reducible by stannous chloride into prostaglandin F(2alpha), thus indicating the involvement of endogenous prostaglandsin endoperoxides in platelet aggregation.
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Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.
P Borgeat,B Samuelsson +1 more
TL;DR: A new metabolite of arachidonic acid, 5-D-(S),12- D-(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid, was found upon incubation of the fatty acid with a suspension of rabbit peritoneal polymorphonuclear leukocytes collected 4 h after injection of glycogen into theperitoneal cavity.
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Practical Procedure for Estimation of Corticosterone or Hydrocortisone
TL;DR: A simplified fluorometric procedure for corticosterone or hydrocortisone has been described and has practical applications for the estimation of these steroids in samples that are small in volume or low in concentration, or in studies that are designed primarily to demonstrate increases or decreases in adrenocortical hormones in plasma or adrenals without requiring absolute specificity.
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Metabolism of arachidonic acid in ionophore-stimulated neutrophils. Esterification of a hydroxylated metabolite into phospholipids.
TL;DR: The esterification of 5-HETE, a hydroxylated fatty acid, into membrane phospholipids may be an example of a more generalized mechanism for altering membrane characteristics.
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Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.
TL;DR: All eight trihydroxy acids, formed by omega- or (omega-1)-hydroxylation of the four vic-diols, four vic -diol dicarboxylic acids, and other metabolites were identified by gas chromatography-mass spectrometry.