Journal ArticleDOI
Is neopterin level a predictive and differential biomarker in patients with thyroid disorders
Tevfik Tolga Sahin,Osman Yüksel,Gözde Girgin,Hande Sipahi,Kürşat Dikmen,Cem Azili,Ferit Taneri,Terken Baydar +7 more
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TLDR
Neopterin seems to be a differential biomarker for malignant and benign thyroid disorders, and monitoring of urinary neopterin profile may be used in early diagnosis of papillary thyroid cancer.Abstract:
Neopterin production provides information about the extent of cellular immune activation. Measurement of neopterin levels may also provide predictive and prognostic information in patients with malignant thyroid diseases. In the present study, neopterin levels were investigated in patients with thyroid disorders (no.=68). Twenty-four patients had papillary thyroid cancers and the rest of them benign thyroid disorders. Results were compared with a healthy control group (no.=30). It was observed that there was a significant difference in neopterin levels between the control group and the thyroid disorders group (p<0.05). The mean neopterin levels in malignant and benign patients were also significantly different (p<0.05). Monitoring of urinary neopterin profile may be used in early diagnosis of papillary thyroid cancer. Neopterin seems to be a differential biomarker for malignant and benign thyroid disorders.read more
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Clinical value of serum neopterin, tissue polypeptide-specific antigen and CA19-9 levels in differential diagnosis between pancreatic cancer and chronic pancreatitis.
Renata Talar-Wojnarowska,Anita Gasiorowska,Marek Olakowski,Andrzej Lekstan,Paweł Lampe,Ewa Małecka-Panas +5 more
TL;DR: Neopterin may be potentially useful in differential diagnosis between PA and CP, and assessment of TPS probably adds no significant information to that obtained with CA19-9 and neopterin.
Journal ArticleDOI
Evaluation of proinflammatory cytokine and neopterin levels in women with papillary thyroid carcinoma
Kemal Beksac,Cigdem Sonmez,Bahadır Çetin,Gorkem Kismali,Tevhide Sel,Yildirim Tuncer,Funda Kosova +6 more
TL;DR: Serum neopterin seems to be a valid biological marker supporting the presence of papillary thyroid cancer, and was higher in presurgical samples and returned to normal following surgery.
Journal ArticleDOI
Neopterin and biopterin levels and tryptophan degradation in patients with diabetes.
TL;DR: The study showed that Kyn/Trp was altered in diabetes patients due to immune modulation and although xenobiotic exposure may change pteridine levels, metformin and/or vildagliptin use in T2DM patients did not have any effect on the measured parameters.
Journal ArticleDOI
Determination of serum neopterin levels in patients with autoimmune thyroid diseases
TL;DR: Higher level of serum neopterin reflects an underlying autoimmune process, and does not correlate with changes in thyroid hormone levels, and can be an important indicator in the exacerbation of autoimmune processes.
Journal ArticleDOI
A New Diagnostic and Prognostic Marker in Endometrial Cancer: Neopterin
Esra Isci Bostanci,Asiye Ugras Dikmen,Gözde Girgin,Tayfun Gungor,Terken Baydar,Ahmet Nuri Danisman +5 more
TL;DR: Using neopterin and cancer antigen 125 together would be useful in determining the prognosis of endometrial cancer and its posttreatment progression, as well as the stage of the disease in women with endometricrial cancer.
References
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Journal ArticleDOI
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.
Ch. Huber,J R Batchelor,Dietmar Fuchs,Arno Hausen,A. Lang,Dietger Niederwieser,Gilbert Reibnegger,P. Swetly,Jakob Troppmair,H. Wachter +9 more
TL;DR: It is demonstrated that macrophages stimulated with supernatant from activated T cells release large amounts of neopterin into culture supernatants, indicating that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines.
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Neopterin as a Marker for Immune System Activation
TL;DR: Neopterin production provides prognostic information in patients with malignant tumor diseases and in HIV-infected individuals, high levels being associated with poorer survival expectations and the extent of oxidative stress can be estimated by neopterin measurements.
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Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy.
TL;DR: It is concluded that conservative thyroid surgery in the form of lobectomy, without neck dissection or prophylactic administration of iodine 131 (131I), constitutes adequate therapy for most cases of papillary thyroid carcinoma.
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Papillary carcinoma of the thyroid
TL;DR: The purpose of this study was to evaluate the clinical significance of multicentricity of papillary carcinoma by determining the incidence of recurrent carcinoma in the remaining thyroid gland after primary surgical treatment by extending the time interval from 1930 to 1966.
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The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases.
TL;DR: Results of neopterin measurements agree with the important role that the cellular immune system plays in these disorders, including autoimmune disorders and certain malignant diseases.