Journal ArticleDOI
Is the Hippocampus Involved in Temporal Discrimination and the Memory of Short Intervals
TLDR
The hippocampus is neither necessary for accurate timing behavior nor for the memory of temporal events, and was concluded that all rats used the stop rule which required the use of working memory.Abstract:
Rats with lesions to the hippocampus proper and the subiculum were tested for timing behavior and temporal memory. Using the peak procedure, they were trained to discriminate a 40 s interval and a retention gap tested the memory for time. Results were interpreted within the theoretical framework of the internal clock and with respect to current theories on hippocampal function. Timing behavior was unaffected by either lesion and no shifts in the temporal discrimination functions were observed. The lesions also failed to show a deficit in the memory for temporal events. For all groups, the retention gap increased the mean peak time by the time of the gap. This indicated that all rats used the stop rule which required the use of working memory. Thus, it was concluded that the hippocampus is neither necessary for accurate timing behavior nor for the memory of temporal events.read more
Citations
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Journal ArticleDOI
Neural systems implicated in delayed and probabilistic reinforcement
TL;DR: This review considers the theoretical problems facing agents that must learn and choose on the basis of reward or reinforcement that is uncertain or delayed, in implicit or procedural (stimulus-response) representational systems and in explicit or declarative (action-outcome-value) representingational systems.
Journal ArticleDOI
Is the avian hippocampus a functional homologue of the mammalian hippocampus
TL;DR: The findings suggest that the avian hippocampus is a functional homologue of the mammalian hippocampus, and that in both birds and mammals the hippocampus is important for the processing and retention of spatial, rather than purely visual information.
Journal ArticleDOI
Neural representation of interval encoding and decision making
Deborah L. Harrington,Lara A. Boyd,Andrew R. Mayer,Daniel Sheltraw,Roland R. Lee,Mingxiong Huang,Stephen M. Rao +6 more
TL;DR: Event-related functional magnetic resonance imaging was used to differentiate neural systems involved in formulating representations of time from processes associated with making decisions about their duration and to support the independence of systems that mediate interval encoding and decision processes.
Journal ArticleDOI
Hippocampal lesions facilitate instrumental learning with delayed reinforcement but induce impulsive choice in rats
TL;DR: The view that the hippocampus hinders action- outcome learning with delayed outcomes is supported, perhaps because it promotes the formation of context-outcome associations instead.
Journal ArticleDOI
Neural Correlates of Interval Timing in Rodent Prefrontal Cortex
TL;DR: The results suggest that the mPFC might be part of an internal clock in charge of controlling interval-timing behavior, and that linearly changing neuronal activity on a logarithmic time scale might be one way of representing the elapse of time in the brain.
References
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Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
Journal ArticleDOI
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
TL;DR: The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.
Book
The prefrontal cortex
TL;DR: The Prefrontal Cortex, Fifth Edition, provides users with a thoroughly updated version of this comprehensive work that has historically served as the classic reference on this part of the brain.
Book
The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe
TL;DR: Anatomy of the prefrontal cortex chemical neurotransmission animal neuropsychological neurophysiology human neuropsychology neuroimaging overview of prefrontal functions - the temporal organization of behaviour.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.