Isolated foveal hypoplasia.
TLDR
Fluorescein angiography revealed a variable and incomplete filtering effect of the choroidal fluorescence in the macular area, suggesting abnormalities in the amount and distribution of macular pigments, and suggests foveal hypoplasia may be more common than is generally believed.Abstract:
Fifteen patients presented with foveal hypoplasia as an isolated ocular finding. The characteristic findings associated with this entity are a visual acuity of 6/21 or worse, nystagmus, and a typical ophthalmoscopic appearance of the macular area, including absent or abnormal maculofoveal reflexes, unclear definition of the maculofoveal area, and capillaries running abnormally close to the presumed macular area, some of them even crossing the horizontal meridian. Fluorescein angiography revealed a variable and incomplete filtering effect of the choroidal fluorescence in the macular area, suggesting abnormalities in the amount and distribution of macular pigments. The fundal findings of isolated foveal hypoplasia, although typical, are very subtle and often difficult to detect, especially because of the accompanying nystagmus. For this reason we suspect that foveal hypoplasia may be more common than is generally believed.read more
Citations
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Journal ArticleDOI
The primate fovea: Structure, function and development.
Andreas Bringmann,Steffen Syrbe,Katja Görner,Johannes Kacza,Mike Francke,Peter Wiedemann,Andreas Reichenbach +6 more
TL;DR: A better understanding of the molecular, cellular, and mechanical factors involved in the developmental morphogenesis and the structural stabilization of the fovea may help to explain the (patho-) genesis of foveal hypoplasia and macular holes.
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Foveal shape and structure in a normal population.
Sarah Tick,Florence Rossant,Itebeddine Ghorbel,Alain Gaudric,José-Alain Sahel,Philippe Chaumet-Riffaud,Philippe Chaumet-Riffaud,Michel Paques +7 more
TL;DR: Foveal structure strongly correlates with its neurovascular organization and supports a developmental model in which the size of the FAZ determines the extent of centrifugal migration of inner retinal layers, which counteracts in some way the centripetal packing of cone photoreceptors.
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Adaptation of the central retina for high acuity vision: cones, the fovea and the avascular zone.
TL;DR: It is suggested that the advantages of having a pit in central retina are relatively few, and minor, but together work to enhance acuity.
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PAX6 missense mutation in isolated foveal hypoplasia
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Pax genes: regulators of lineage specification and progenitor cell maintenance
Judith A. Blake,Melanie Ziman +1 more
TL;DR: The molecular functions of Pax genes during development are reviewed and the regulatory mechanisms by which they specify and maintain progenitor cells across various tissue lineages are detailed.
References
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Journal ArticleDOI
The Morphological Development of the Human Fovea
TL;DR: As judged by anatomical criteria and compared to normal adult foveas similarly processed, the human fovea reaches maturity between 15 and 45 months of age.
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Isolated foveal hypoplasia.
Robert E. Curran,Richard M. Robb +1 more
TL;DR: In patients with varying degrees of congenital nystagmus and poor visual acuity, but no evidence of albinism or aniridia, isolated foveal hypoplasia may be more common as a cause of congenitals sensory nyStagmus than has been appreciated in the past.
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Development of macular vessels in monkey and cat.
TL;DR: Preliminary observations are made on the development of macular vessels in the rhesus monkey and the cat, an animal with a distinct area centralis, but no fovea.
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Autosomal dominant foveal hypoplasia and presenile cataracts. A new syndrome.
TL;DR: An autosomal dominant syndrome of mild foveal hypoplasia (visual acuity, 20/50), congenital nystagmus, corneal pannus, and presenile cataracts was seen in four patients from a single family.
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Foveal hypoplasia and bilateral 360-degree peripheral retinal rosettes.
TL;DR: The relationship of foveal hypoplasia to peripheral retinal rosettes in this case may have been caused by an intercurrent infection during the late stages of embryogenesis.