Journal ArticleDOI
Isolation and preliminary characterization of Escherichia coli mutants resistant to lethal action of the bacteriophage λ P gene
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TLDR
Two types of spontaneous and NTG-induced mutants of Escherichia coli 594 insensitive to the lethal action of λ P gene were isolated and called rpl, showing different phenotypes.About:
This article is published in Virology.The article was published on 1991-05-01. It has received 9 citations till now. The article focuses on the topics: Lambda phage.read more
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Journal ArticleDOI
Fine Tuning and Cross-talking of TGF-β Signal by Inhibitory Smads
TL;DR: Exploring the molecular mechanisms about the regulations of ISmads may provide the therapeutic clues for human diseases induced by the abnormal TGF-β signaling, which is implicated in the pathogenesis of human diseases.
Journal ArticleDOI
The Bacteriophage λ DNA Replication Protein P Inhibits the oriC DNA- and ATP-binding Functions of the DNA Replication Initiator Protein DnaA of Escherichia coli
TL;DR: It is concluded that the lambda P protein inhibits the binding of oriC DNA and ATP to the wild-type DnaA protein, which causes the inhibition of host DNA synthesis initiation that ultimately leads to bacterial death.
Journal ArticleDOI
Genes that protect against the host-killing activity of the E3 protein of Bacillus subtilis bacteriophage SPO1.
Ping Wei,Charles R. Stewart +1 more
TL;DR: A cloned rpoB gene, specifying an apparently mutantRNA polymerase beta subunit, protected Escherichia coli against the cytocidal effects of the E3 protein of bacteriophage SPO1, suggesting that RNA polymerase is the primary cellular target of theE3 protein.
Journal ArticleDOI
The Mutation that Makes Escherichia coli Resistant to λ P Gene-mediated Host Lethality Is Located within the DNA Initiator Gene dnaA of the Bacterium
Indrani Datta,Sarbani Banik-Maiti,Lopa Adhikari,Subrata Sau,Niranjan Das,Nitai Chandra Mandal +5 more
TL;DR: It is shown that under the lambda P gene-mediated lethal condition, the host DNA synthesis is inhibited at the initiation step, and it is concluded that the rpl mutations, which make E. coli resistant to lambda PGene-mediated host lethality, are located within the DNA initiator gene dnaA of the host.
Journal ArticleDOI
Bacteriophage λ P gene shows host killing which is not dependent on λ DNA replication
TL;DR: It is concluded that the higher levels of P protein, produced either when cro has the hk mutation or when tR1 is deleted, are lethal to the host.
References
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Journal ArticleDOI
Physical interactions between bacteriophage and Escherichia coli proteins required for initiation of lambda DNA replication.
TL;DR: The results show that the dnaK protein specifically interacts with both lambda O and lambda P, and that thednaJ protein specifically interact with the dnB helicase, which unwinds the duplex DNA template at the replication fork.
Journal ArticleDOI
Mechanism of λc17cI virulence
W.S. Sly,K. Rabideau +1 more
TL;DR: It was proposed that λc 17 cI is virulent because its constitutive replication leads to oversaturation of the cI + repressor produced by the prophage and this leads to expression of genes which were initially subject to repression in the input λ c 17 ci .
Journal ArticleDOI
Studies on polylysogens containing λN−cl− prophages I. control of synthesis and maintenance of a large number of integrated λ genomes
TL;DR: Results indicate that the maintenance of 20–25 copies of integrated phage genome in λ N − c I − polylysogens is the result of both passive and O and P protein-mediated synthesis, and that the latter may be regulated by the cro gene product.
Journal ArticleDOI
Bacteriophage λ P gene shows host killing which is not dependent on λ DNA replication
TL;DR: It is concluded that the higher levels of P protein, produced either when cro has the hk mutation or when tR1 is deleted, are lethal to the host.
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C Braun-Breton,M Hofnung +1 more