Journal ArticleDOI
Isolation and synthesis of biologically active carbazole alkaloids
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This article is published in Chemical Reviews.The article was published on 2002-11-13. It has received 1143 citations till now. The article focuses on the topics: Carbazole.read more
Citations
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Practical methodologies for the synthesis of indoles.
Journal ArticleDOI
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
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Recent advances in aryl–aryl bond formation by direct arylation
TL;DR: Compared to traditional methods, direct arylation affords Ar-Ar compounds in fewer steps by removing the need for prefunctionalisation, and given that either one or two hydrogens are targeted, less waste and good atom economy are features of this methodology.
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Combined C-H functionalization/C-N bond formation route to carbazoles.
TL;DR: A new method in which a series of substituted carbazoles is efficiently produced by the combination of an amide and an arene is described, which tolerates substitution on either ring of the biaryl amide substrates.
References
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
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Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
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Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
TL;DR: Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca++dependent protein kinase (protein kinase C) from rat brain, with an IC50 value of 2.7 nM.
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Catalytic asymmetric epoxidation and kinetic resolution: modified procedures including in situ derivatization
TL;DR: The use of 3A or 4A molecular sieves substantially increases the scope of the titanium(IV)-catalyzed asymmetric epoxidation of primary allylic alcohols as mentioned in this paper.
Journal ArticleDOI
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.
Georg Martiny-Baron,Marcelo G. Kazanietz,Harald Mischak,Peter M. Blumberg,Georg Kochs,Hubert Hug,Dieter Marmé,Christoph Schächtele +7 more
TL;DR: In vitro kinase assays indicated that interference with Ca2+ or its binding site is not responsible for the differential inhibition of PKC isozymes by Gö 6976, and Kinetic analysis revealed that PKC inhibition by Gö 7076 was competitive with respect to ATP, non-competitive withrespect to the protein substrate, and mixed type with respectto phosphatidylserine.