Journal ArticleDOI
Isolation, characterization and biological activity of a diuretic myokinin neuropeptide from the housefly, Musca domestica
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TLDR
The diuretic activity of muscakinin is more than double that of a previously identified CRF-related diuretics peptide (Musca-DP) from the housefly, and the two peptides act synergistically in stimulating fluid secretion.About:
This article is published in Peptides.The article was published on 1999-01-01. It has received 87 citations till now. The article focuses on the topics: Housefly & Peptide synthesis.read more
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Journal ArticleDOI
Neuropeptides in the nervous system of Drosophila and other insects: multiple roles as neuromodulators and neurohormones.
TL;DR: Drosophila, in spite of its small size, is now emerging as a very favorable organism for the studies of neuropeptide function due to the arsenal of molecular genetics methods available.
Journal ArticleDOI
Mono- and dibasic proteolytic cleavage sites in insect neuroendocrine peptide precursors.
TL;DR: Rules to predict proteolytic cleavage sites at basic amino acids in insect neuropeptide precursors are established and it is likely that, as in vertebrates, ambiguous processing sites exist to allow differential cleavage of the same precursor by different convertases and it seems possible that the precursor of allatostatins and PBAN are differentially cleaved in different cell types.
Journal ArticleDOI
Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles.
TL;DR: A functional genomic approach has yielded the first complete characterization of a leucokinin receptor in an insect, and its properties match closely those reported for the action of Drosokinin on Malpighian (renal) tubules.
Book ChapterDOI
Insect diuretic and antidiuretic hormones
TL;DR: Consideration is given to the evidence for diuretic and antidiuretic factors functioning as circulating neurohormones to regulate Malpighian tubule secretion and hindgut reabsorption in vivo and to how their activities are integrated for the maintenance of haemolymph volume and composition.
Journal ArticleDOI
The Drosophila melanogaster homologue of an insect calcitonin-like diuretic peptide stimulates V-ATPase activity in fruit fly Malpighian tubules.
TL;DR: The Droseophila melanogaster homologue of an insect calcitonin-like diuretic hormone was identified in a BLAST search of the Drosophila genome database and the predicted 31-residue amidated peptide was synthesised and tested for activity on fruit fly Malpighian tubules.
References
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Journal ArticleDOI
Progress in Comparative Endocrinology
TL;DR: This book is a handsome volume containing the proceedings of the Third International Symposium on Comparative Endocrinology, which was held at Oiso, Japan, June 5-11, 1961.
Journal ArticleDOI
Separate control of anion and cation transport in malpighian tubules of Drosophila Melanogaster.
TL;DR: Results show that leucokinin acts through intracellular Ca2+, independently of cyclic AMP or cyclic GMP, to raise the chloride permeability of the epithelium, and there is a clear functional separation between the control pathways acting on cation and anion transport in the tubules.
Journal ArticleDOI
Leucokinins, a new family of ion transport stimulators and inhibitors in insect Malpighian tubules.
Timothy K. Hayes,Thomas L. Pannabecker,D.J. Hinckley,G.M. Holman,Ronald J. Nachman,D.H. Petzel,Klaus W. Beyenbach +6 more
TL;DR: The finding of effects in mosquito Malpighian tubules suggests that leucokinins may be widely distributed in insects where they may have diverse functions in a variety of organs.
Journal ArticleDOI
Cell-type specific calcium signalling in a Drosophila epithelium
TL;DR: Assays for epithelial function confirm that calcium entry is essential for CAP2b to induce a physiological response in the whole organ and suggest a role for calcium signalling in the modulation of the nitric oxide signalling pathway in this epithelium.
Journal ArticleDOI
Isolation, primary structure and synthesis of two neuropeptides from Leucophaea maderae: Members of a new family of cephalomyotropins☆
TL;DR: A series of four high-performance liquid-chromatographie (HPLC) fractionations yielded sufficient quantities of pure peptides for micro amino acid analyses and primary sequence determinations of two peptides which stimulate the contractile activity of the cockroach hindgut.