Journal ArticleDOI
L-Arginine Inhibits Balloon Catheter-Induced Intimal Hyperplasia
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TLDR
L-arginine administration from 2 days prior to and 2 weeks following catheter-induced injury to the rabbit thoracic aorta attenuated the development of intimal hyperplasia by 39% as compared with untreated controls, suggesting that the mechanism for this effect is the conversion of L- arginine to nitric oxide.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1993-05-28. It has received 227 citations till now. The article focuses on the topics: Intimal hyperplasia & Balloon catheter.read more
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Journal ArticleDOI
The Intima: Soil for Atherosclerosis and Restenosis
TL;DR: The developmental origins of the intima are discussed and it is suggested that the arterial intima is a distinct tissue with a long and …
Journal ArticleDOI
Molecular mechanisms and therapeutic strategies related to nitric oxide.
Salvador Moncada,E. A. Higgs +1 more
TL;DR: A brief overview will discuss some possible interventions in the L‐arginine:NO pathway and the potential benefits as well as undesirable side effects that might arise from them.
Journal ArticleDOI
Nitric oxide synthase: role in the genesis of vascular disease.
John P. Cooke,Victor J. Dzau +1 more
TL;DR: Insights into the mechanisms by which NO production or activity is altered in these states will lead to new therapeutic strategies in the treatment of a number of vascular disorders, including hypertension, atherosclerosis, restenosis, and thrombosis.
Journal ArticleDOI
The vascular protective effects of estrogen.
TL;DR: Like other steroids, the effect of estrogen on the vessel wall has a rapid nongenomic component involving membrane phenomena, such as alteration of membrane ionic permeability and activation of membrane‐bound enzymes, as well as the classical genomic effect involving estrogen receptor activation and gene expression.
Journal ArticleDOI
Does ADMA cause endothelial dysfunction
TL;DR: Plasma levels of this inhibitor of nitric oxide synthase are elevated in patients with atherosclerosis and in those with risk factors for Atherosclerosis, suggesting that ADMA may be a novel risk factor for vascular disease.
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Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
Uttam Garg,Aviv Hassid +1 more