Lateral Habenula Involvement in Impulsive Cocaine Seeking
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TLDR
Results indicate that the LHb participates in the suppression of impulsive responding for cocaine through the activation of a cholinergic circuit, and they suggest that LHb dysfunction may contribute to impaired impulse control associated with drug addiction.About:
This article is published in Neuropsychopharmacology.The article was published on 2017-04-01 and is currently open access. It has received 32 citations till now.read more
Citations
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The transition to compulsion in addiction.
TL;DR: This Review integrates accounts of the neuropharmacological mechanisms that underlie the transition to compulsion with overarching learning theories, to outline how compulsion develops in addiction, highlighting the conceptual distinctions between compulsive drug-seeking behaviour and compulsivedrug-taking behaviour.
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The thalamus in drug addiction: from rodents to humans.
TL;DR: Findings from the animal literature suggest that the paraventricular nucleus of the thalamus, the lateral habenula and the mediodorsal nucleus may be involved in the reinstatement, extinction and expression of drug-seeking behaviours.
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Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving.
Daniel S. Zahm,David H. Root +1 more
TL;DR: In considering the afferent and efferent connections of the LHb some attention is given to the relative validity of regarding it as a bi-partite structure featuring 'limbic' and 'pallidal' parts.
Journal Article
Animal studies of addictive behavior
TL;DR: Empirical evidence is summarized for the occurrence of several DSM-IV-like symptoms of addiction in animals after extended drug use, which it is hoped will ultimately lead to the development of more effective treatments for this devastating disorder.
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Dorsal raphe projection inhibits the excitatory inputs on lateral habenula and alleviates depressive behaviors in rats.
Hai Zhang,Kuan Li,Hong-Sheng Chen,Shuang-Qi Gao,Zhi-Xuan Xia,Jie-Ting Zhang,Fang Wang,Jian-Guo Chen +7 more
TL;DR: It is demonstrated that the 5-HT projection from DRN to LHb suppresses the excitability of LHb neurons, and hypofunction of 5- HT transmission induces depressive behavior via the activation of LH b.
References
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Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy
TL;DR: This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats to examine psychostimulant and opiate reinforcement.
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Lateral habenula as a source of negative reward signals in dopamine neurons
TL;DR: It is shown that the primate lateral habenula, part of the structure called the epithalamus, is a major candidate for a source of negative reward-related signals in dopamine neurons, and the inhibitory input from the lateral ha benula plays an important role in determining the reward- related activity of dopamine neurons.
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Impulsivity as a determinant and consequence of drug use: a review of underlying processes
TL;DR: In this paper, the authors reviewed data from controlled studies investigating different measures of impulsive behaviors, including delay discounting, behavioral inhibition and a newly proposed measure of inattention, and found that drugs of abuse alter performance across independent behavioral measures of impulsivity.
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Evidence for addiction-like behavior in the rat.
TL;DR: It is reported that behaviors that resemble three of the essential diagnostic criteria for addiction appear over time in rats trained to self-administer cocaine.
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High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
TL;DR: Experimental evidence is shown that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction.