Left Ventricular Noncompaction : A Distinct Genetic Cardiomyopathy?
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TLDR
The prevalence of LVNC in healthy athletes, its possible reversibility, and increasing diagnosis in healthy subjects suggests cautious use of the term LVNC cardiomyopathy, which describes the morphology but not the functional profile of the cardiopathy.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2016-08-30 and is currently open access. It has received 194 citations till now. The article focuses on the topics: Left ventricular noncompaction & Cardiomyopathy.read more
Citations
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Journal ArticleDOI
Left ventricular noncompaction cardiomyopathy: cardiac, neuromuscular, and genetic factors
TL;DR: The current findings on the aetiology and pathophysiology of LVHT are discussed, and an overview of the diagnosis, available treatment, and prognosis of this cardiomyopathy is provided.
Journal ArticleDOI
Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association.
Kiran Musunuru,Farah Sheikh,Rajat M. Gupta,Steven R. Houser,Kevin O. Maher,David J. Milan,Andre Terzic,Joseph C. Wu +7 more
TL;DR: This statement comprehensively describes the provenance of iPSC lines, their use for cardiovascular disease modeling, theirUse for precision medicine, and strategies through which to promote their wider use for biomedical applications.
Journal ArticleDOI
Heart Failure in Pediatric Patients With Congenital Heart Disease.
TL;DR: The objective of this review is to provide a framework for understanding rapidly increasing genetic and molecular information in the challenging context of detailed phenotyping.
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Novel Genetic Triggers and Genotype–Phenotype Correlations in Patients With Left Ventricular Noncompaction
Karol Miszalski-Jamka,John L. Jefferies,Wojciech Mazur,Jan Głowacki,Jianhong Hu,Monika Lazar,Richard A. Gibbs,Jacek Liczko,Jan Kłyś,Eric Venner,Donna M. Muzny,Jarosław Rycaj,Jacek Białkowski,Ewa Kluczewska,Zbigniew Kalarus,Shalini N. Jhangiani,Hussein R. Al-Khalidi,Tomasz Kukulski,James R. Lupski,William J. Craigen,Matthew N. Bainbridge +20 more
TL;DR: LVHT and LVNC likely represent a continuum of genotypic disease with differences in severity and variable phenotype explained, in part, by the number of VOIs and whether mutations are present in sarcomeric or nonsarcomeric genes.
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A systematic review and meta-analysis of the prevalence of left ventricular non-compaction in adults.
Samantha Barratt Ross,Katherine Jones,Bianca Blanch,Rajesh Puranik,Rajesh Puranik,Kevin McGeechan,Alexandra Barratt,Christopher Semsarian +7 more
TL;DR: Left ventricular non-compaction in adult populations is a poorly defined entity which likely encompasses both physiological adaptation and pathological disease and there is significant potential for overdiagnosis, overtreatment, and unnecessary follow-up.
References
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Contemporary Definitions and Classification of the Cardiomyopathies An American Heart Association Scientific Statement From the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention
Barry J. Maron,Jeffrey A. Towbin,Gaetano Thiene,Charles Antzelevitch,Domenico Corrado,Donna K. Arnett,Arthur J. Moss,Christine E. Seidman,James B. Young +8 more
TL;DR: The present classification scheme recognizes the rapid evolution of molecular genetics in cardiology, as well as the introduction of several recently described diseases, and is unique in that it incorporates ion channelopathies as a primary cardiomyopathy.
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2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)
TL;DR: In this article, the authors proposed AMIOdarone versus implantable cardioverter-defibrillator (ICD-DV) for the treatment of atrial fibrillation.
Journal ArticleDOI
Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases
Perry M. Elliott,Bert Andersson,Eloisa Arbustini,Zofia T. Bilińska,Franco Cecchi,Philippe Charron,Olivier Dubourg,Uwe Kühl,Bernhard Maisch,William J. McKenna,Lorenzo Monserrat,Sabine Pankuweit,Claudio Rapezzi,Petar M. Seferović,Luigi Tavazzi,Andre Keren +15 more
TL;DR: This document, The European Society of Cardiology Working Group on Myocardial and Pericardial Diseases presents an update of the existing classification scheme, to help clinicians look beyond generic diagnostic labels in order to reach more specific diagnoses.
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Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy
TL;DR: It is suggested that the WHO classification of cardiomyopathies be reconsidered to include IVNC as a distinctCardiomyopathy.
Journal ArticleDOI
Left ventricular non-compaction - Insights from cardiovascular magnetic resonance imaging
Steffen E. Petersen,Joseph B. Selvanayagam,Joseph B. Selvanayagam,Frank Wiesmann,Frank Wiesmann,Matthew D. Robson,Matthew D. Robson,Jane M Francis,Jane M Francis,Robert H. Anderson,Hugh Watkins,Stefan Neubauer,Stefan Neubauer +12 more
TL;DR: In this article, the diagnostic accuracy of cardiovascular magnetic resonance (CMR) imaging in distinguishing pathological left ventricular non-compaction (LVNC) from lesser degrees of trabecular layering seen in healthy volunteers and, in those with cardiomyopathies and concentric left-ventricular hypertrophy, potential differential diagnoses was evaluated.