J
John L. Jefferies
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 257
Citations - 7805
John L. Jefferies is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Heart failure & Cardiomyopathy. The author has an hindex of 40, co-authored 218 publications receiving 6175 citations. Previous affiliations of John L. Jefferies include Boston Children's Hospital & St Lukes Episcopal Hospital.
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Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial
Iacopo Olivotto,Artur Oreziak,Roberto Barriales-Villa,Theodore P. Abraham,Ahmad Masri,Pablo García-Pavía,Pablo García-Pavía,Sara Saberi,Neal K. Lakdawala,Matthew T. Wheeler,Anjali T. Owens,Milos Kubanek,Wojciech Wojakowski,Morten Kvistholm Jensen,Juan Ramón Gimeno-Blanes,Kia Afshar,Jonathan Myers,Jonathan Myers,Sheila M. Hegde,Scott D. Solomon,Amy J. Sehnert,David Zhang,Wanying Li,Mondira Bhattacharya,Jay M. Edelberg,Cynthia Burstein Waldman,Steven J. Lester,Andrew Wang,Carolyn Y. Ho,Daniel Jacoby,Jozef Bartunek,Antoine Bondue,Emeline Van Craenenbroeck,David Zemanek,Morten Søndergaard Jensen,Jens Mogensen,Jens Jakob Thune,Philippe Charron,Albert Hagège,Olivier Lairez,Jean Noël Trochu,Christoph Axthelm,Hans Dirk Duengen,Norbert Frey,Veselin Mitrovic,Michael Preusch,Jeanette Schulz-Menger,Tim Seidler,Michael Arad,Majdi Halabi,Amos Katz,Daniel Monakier,Offir Paz,Samuel Viskin,Donna R. Zwas,Hans-Peter Brunner-La Rocca,Michelle Michels,Dariusz Dudek,Zofia Oko-Sarnowska,Nuno Cardim,Helder Pereira,Pablo García Pavia,Juan Ramon Gimeno Blanes,Rafael Hidalgo Urbano,Luis Miguel Rincón Diaz,Perry M. Elliott,Zaheer Yousef,Theodore Abraham,Paulino Alvarez,Richard G. Bach,Richard C. Becker,Lubna Choudhury,David Fermin,John L. Jefferies,Christopher M. Kramer,Neal K. Lakdawala,Steven Lester,Ali J. Marian,Mathew S. Maurer,Sherif F. Nagueh,David R. Owens,Florian Rader,Mark V. Sherrid,Jamshid Shirani,John Symanski,Aslan T. Turer,Omar Wever-Pinzon,Timothy C. Wong,Mohamad H. Yamani +88 more
TL;DR: Treatment with mavacamten improved exercise capacity, LVOT obstruction, NYHA functional class, and health status in patients with obstructive hypertrophic cardiomyopathy and highlights the benefits of disease-specific treatment for this condition.
Journal ArticleDOI
Congenital heart surgery in infants: effects of acute kidney injury on outcomes.
Joshua J. Blinder,Stuart L. Goldstein,Vei-Vei Lee,Alixandra Baycroft,Charles D. Fraser,Charles D. Fraser,David L. Nelson,John L. Jefferies,John L. Jefferies +8 more
TL;DR: Perioperative acute kidney injury is common in infant heart surgery and portends a poor clinical outcome and was associated with systemic ventricular dysfunction at hospital discharge.
Journal ArticleDOI
Left ventricular non-compaction cardiomyopathy.
TL;DR: Treating of arrhythmia and implantation of an automatic implantable cardioverter-defibrillator for prevention of sudden death are mainstays of therapy when deemed necessary and appropriate in patients with systolic dysfunction.
Journal ArticleDOI
Genetic predictors and remodeling of dilated cardiomyopathy in muscular dystrophy.
John L. Jefferies,Benjamin W. Eidem,John W. Belmont,William J. Craigen,Stephanie M. Ware,Susan D. Fernbach,Steven R. Neish,E. O'Brian Smith,Jeffrey A. Towbin +8 more
TL;DR: Early diagnosis and treatment of DCM may lead to ventricular remodeling in DMD/BMD patients and specific dystrophin gene mutations appear to be predictive of cardiac involvement, while other mutations may protect against or inhibit development ofDCM.
Journal ArticleDOI
Mortality and Sudden Death in Pediatric Left Ventricular Noncompaction in a Tertiary Referral Center
Samuel T. Brescia,Joseph W. Rossano,Ricardo H. Pignatelli,John L. Jefferies,Jack F. Price,Jamie A. Decker,Susan W. Denfield,W. Jeffrey Dreyer,O’Brian Smith,Jeffrey A. Towbin,Jeffrey J. Kim +10 more
TL;DR: Left ventricular noncompaction has a high mortality rate and is strongly associated with arrhythmias in children, and preceding cardiac dysfunction or ventricular arrh rhythmias are associated with increased mortality.