Journal ArticleDOI
Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet.
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TLDR
The consumption of the safflower oil diet increased lipoprotein lipase activity in heart and skeletal muscle, resulting in the elevation of fat oxidation rate and the depression of serum triacylglycerol level, suggesting greater diet-induced thermogenesis in the former group.Abstract:
The effects on body fat accumulation of long-term feeding of high fat diets of differing fatty acid composition were studied in rats. The rats were meal-fed isoenergetic diets based on safflower oil or beef tallow for 4 mo. Each diet was freshly prepared every day throughout the experimental period. Oxygen consumption and carbon dioxide production for 6 h after meals were measured between the 50th and 54th d of the experimental period. Oxygen consumption for 3 h after meals was significantly greater in the safflower oil diet group than in the beef tallow diet group, indicating greater diet-induced thermogenesis in the former group. From the assessment of respiratory quotient, the fat oxidation rate was also higher in the former. After the experimental period (4 mo), body fat accumulation was significantly less in the rats fed safflower oil. This difference was, at least in part, ascribed to increased diet-induced thermogenesis and fat oxidation. Serum triacylglycerol level was markedly lower in the rats fed safflower oil than in those fed beef tallow. The lipoprotein lipase activities in heart and soleus muscle after meals appeared to be higher in the former than in the latter. These results suggest that the consumption of the safflower oil diet increased lipoprotein lipase activity in heart and skeletal muscle, resulting in the elevation of fat oxidation rate and the depression of serum triacylglycerol level.read more
Citations
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Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
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Dietary fat and adipose tissue metabolism in ruminants, pigs, and rodents: a review.
TL;DR: Dietary fat decreased de novo fatty acid synthesis and basal glycerol release in adipose tissue and tended to increase simultaneously beta-adrenergic lipolytic responses to increased membrane fluidity and a trend toward insulin resistance, which was more marked with saturated fatty acids, occurred in adipOSE tissue.
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Dietary fats and membrane function: implications for metabolism and disease
TL;DR: The understanding of dietary lipid profile and its influence on membrane function in relation to metabolic dysregulation has exciting potential for the prevention and treatment of a range of prevalent disease states.
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Dietary fats and insulin action
Leonard H Storlien,Louise A. Baur,A. D. Kriketos,D. A. Pan,D. A. Pan,Gregory J. Cooney,Arthur B. Jenkins,G. D. Calvert,Lesley V. Campbell +8 more
TL;DR: It was really not until the 1980 s that the development of acceptable techniques for the measurement of insulin action in vivo allowed the relationship between dietary fat intake and insulin action to be accurately assessed.
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Dietary fatty acid profile modifies abdominal fat deposition in broiler chickens
N. Crespo,E. Esteve-Garcia +1 more
TL;DR: It is suggested that polyunsaturated fatty acids produce lower abdominal fat deposition than saturated or monounsaturated fatty acid, whereas polyuns saturated fatty acids were higher in muscle fat.
References
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Journal ArticleDOI
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Carl R Morgan,Arnold Lazarow +1 more
TL;DR: A two antibody system of insulin assay for immunoassay of insulin induces the production of specific nonprecipitating antibodies, both in experimental animals and in humans.
Journal ArticleDOI
A role for brown adipose tissue in diet-induced thermogenesis
TL;DR: Measurement of energy balance during voluntary over-eating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance and suggests that this tissue may determine metabolic efficiency and resistance to obesity.
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Enzymatic properties of the inner and outer membranes of rat liver mitochondria
TL;DR: The inner membrane-matrix fraction retained a high degree of morphological and biochemical integrity and exhibited a high respiratory rate and respiratory control when assayed in a sucrose-mannitol medium containing EDTA.
Journal ArticleDOI
A stable, radioactive substrate emulsion for assay of lipoprotein lipase.
TL;DR: A method is described for the assay of lipoprotein lipase, using a stable, radioactive substrate emulsion, which is rapid, sensitive and reproducible, and suitable for routine use.
Journal ArticleDOI
Lipolytic Enzymes and Plasma Lipoprotein Metabolism
TL;DR: Detailed analysis of triglycerideRich Lipoproteins: VLDL and Chylomicrons and the effect of substrate composition, regulation of LPL, and other effectors are presented.