Journal ArticleDOI
Leuconostoc dextransucrase and dextran: production, properties and applications
TLDR
This review covers the production, properties and applications of the biopolysaccharide dextran; this biopolymer can be produced via fermentation either with Leuconostoc mesenteroides strains and other lactic acid bacteria or with certain Gluconobacter oxydans strains.Abstract:
This review covers the production, properties and applications of the biopolysaccharide dextran; this biopolymer can be produced via fermentation either with Leuconostoc mesenteroides strains and other lactic acid bacteria or with certain Gluconobacter oxydans strains. The former strains convert sucrose into dextran with the dextransucrase enzyme whereas the latter convert maltodextrins into dextran with the dextran dextrinase enzyme. Emphasis is mainly focused on Leuconostoc strains as producer organisms of dextransucrase and dextran types. In addition to industrial fermentation processes producing the enzymes and/or the dextrans, biocatalysis principles are also being developed, whereby enzyme preparations convert sucrose or maltodextrins, respectively, into (oligo)dextrans. The chemical and physical properties of different dextrans are discussed in detail, together with the characteristics and molecular mode of action of dextransucrase. Subsequently, useful applications of dextran and some problems associated with undesirable formation of dextran are outlined. Copyright © 2005 Society of Chemical Industryread more
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Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications
TL;DR: A wide range of natural-origin polymers with special focus on proteins and polysaccharides that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue engineering field targeting several biological tissues are overviewed.
Journal ArticleDOI
Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends
João F. Mano,Gabriel A. Silva,Helena S. Azevedo,P. B. Malafaya,Rui A. Sousa,Simone S. Silva,Luciano F. Boesel,Joaquim M. Oliveira,Tírcia C. Santos,Alexandra P. Marques,Nuno M. Neves,Rui L. Reis +11 more
TL;DR: In this review, the most studied and promising and recently proposed naturally derived polymers that have been suggested for tissue engineering applications are described and their blends with synthetic polymers are analysed, with special focus on polysaccharides and proteins.
Journal ArticleDOI
Bacterial extracellular polysaccharides involved in biofilm formation.
TL;DR: A summary of the current status of the research into the role of EPS in bacterial attachment followed by biofilm formation and a range of novel techniques that can be used in studies involving biofilm-specific polysaccharides is discussed.
Journal ArticleDOI
Scaffold: A Novel Carrier for Cell and Drug Delivery
TL;DR: The present review gives a detailed account of the need for the development of scaffolds along with the materials used and techniques adopted to manufacture scaffolds for tissue engineering and for prolonged drug delivery.
Journal ArticleDOI
Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications
TL;DR: Owing to its ease of preparation, processability, pH-sensitivity, and biocompatibility, this type of modified dextran should find use in numerous drug delivery applications.
References
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Structures and mechanisms of glycosyl hydrolases
TL;DR: The wealth of information provided by the recent structure determinations of many different glycosyl hydrolases shows that the substrate specificity and the mode of action of these enzymes are governed by exquisite details of their three-dimensional structures rather than by their global fold.
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An improved procedure for the methylation analysis of oligosaccharides and polysaccharides
TL;DR: An improved procedure for the methylation analysis of oligosaccharides and polysaccharides is described, which is convenient, gives high recoveries of acetylated alditols of methylated sugars, and allows analysis of the glycosyl linkages of oligo- or poly-saccharide to be completed within a working day.
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Characterization and Classification of Dextrans from Ninety-six Strains of Bacteria1b
Allene Jeanes,William C. Haynes,C. A. Wilham,J. C. Rankin,E. H. Melvin,Marjorie J. Austin,J. E. Cluskey,B. E. Fisher,H. M. Tsuchiya,C. E. Rist +9 more
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Viscosity, sedimentation, and light-scattering properties of fraction of an acid-hydrolyzed dextran†
TL;DR: In this paper, dextran produced by Leuconostoc mesenteroides NRRL B-512 was acid-hydrolyzed and fractionated, yielding a series of fractions from which 24 were selected that ranged in molecular weight from 17,700 to 9.5 million.