Structures and mechanisms of glycosyl hydrolases
TLDR
The wealth of information provided by the recent structure determinations of many different glycosyl hydrolases shows that the substrate specificity and the mode of action of these enzymes are governed by exquisite details of their three-dimensional structures rather than by their global fold.About:
This article is published in Structure.The article was published on 1995-09-01 and is currently open access. It has received 1873 citations till now.read more
Citations
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Structural and sequence-based classification of glycoside hydrolases.
TL;DR: The diversity of oligo- and polysaccharides provides an abundance of biological roles for these carbohydrates, and the enzymes hydrolysing these compounds, the glycoside hydrolases, mediate a wealth of biological functions.
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An evolving hierarchical family classification for glycosyltransferases.
TL;DR: This evolving classification rationalises structural and mechanistic investigation, harnesses information from a wide variety of related enzymes to inform cell biology and overcomes recurrent problems in the functional prediction of glycosyltransferase-related open-reading frames.
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The abundance and variety of carbohydrate-active enzymes in the human gut microbiota.
Abdessamad El Kaoutari,Abdessamad El Kaoutari,Fabrice Armougom,Jeffrey I. Gordon,Didier Raoult,Bernard Henrissat,Bernard Henrissat +6 more
TL;DR: The carbohydrate-digestive capacity of a simplified but representative mini-microbiome is examined in order to highlight the abundance and variety of bacterial CAZymes that are represented in the human gut microbiota.
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The Cellulosomes: Multienzyme Machines for Degradation of Plant Cell Wall Polysaccharides
TL;DR: The recently described three-dimensional crystal structure of the cohesin-dockerin heterodimer sheds light on the critical amino acids that contribute to this high-affinity protein-protein interaction.
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Novel enzymes for the degradation of cellulose
TL;DR: This work describes recent developments in enzyme technology for conversion of cellulose, the most abundant, homogeneous and recalcitrant polysaccharide in lignocellulosic biomass, and focuses on a recently discovered new type of enzymes currently classified as CBM33 and GH61 that catalyze oxidative cleavage ofpolysaccharides.
References
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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
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A classification of glycosyl hydrolases based on amino acid sequence similarities.
TL;DR: With the steady increase in sequence and structural data, it is suggested that the enzyme classification system should perhaps be revised.
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New families in the classification of glycosyl hydrolases based on amino acid sequence similarities.
TL;DR: On the basis of a comparison of 482 sequences corresponding to 52 EC entries, 45 families, out of which 22 are polyspecific, can now be defined and has been implemented in the SWISS-PROT protein sequence data bank.
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Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2 Angstrom resolution.
C. C. F. Blake,D. F. Koenig,D. F. Koenig,G. A. Mair,A. C. T. North,D. C. Phillips,V. R. Sarma +6 more
TL;DR: Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 A Resolution as mentioned in this paper, 3D Fourier synthesis at 2 a resolution.