Journal ArticleDOI
Liver Ultrasound Attenuation
TLDR
Li et al. as mentioned in this paper compared LiSA's and HRI's performance on NAFLD assessment and found that LiSA is more accurate than HRI in hepatic steatosis (HS) differentiation.Abstract:
Nonalcoholic fatty liver disease (NAFLD) is the most widespread chronic liver disease type in the Western countries. Ultrasound (US) is used for NAFLD and hepatic steatosis (HS) grading. The most popular US method for NAFLD assessment is the hepatorenal index (HRI), but because of its limitations, other noninvasive methods have been developed. The Resona 7 US system has recently incorporated an US attenuation-related quantitative feature, liver ultrasound attenuation (LiSA), for HS estimation. The purpose of this study is to compare LiSA's and HRI's performance on NAFLD assessment.A total of 159 NAFLD patients having a magnetic resonance imaging-proton density fat fraction (MRI-PDFF) examination were examined by 2 radiologists, who performed LiSA and HRI measurements in the liver. Correlation of LiSA's and HRI's measurements with MRI-PDFF values was calculated through Pearson correlation coefficient (PCC). To further investigate the performance of LiSA and HRI, optimum cutoffs, provided by the literature, were used to correspond HS grades to MRI-PDFF results. Moreover, a receiver operating characteristic (ROC) analysis on LiSA measurements and steatosis grades was performed.Magnetic resonance imaging-PDFF was better correlated with LiSA (PCC = 0.80) than HRI (PCC = 0.67). Receiver operating characteristic analysis showed better performance range for LiSA (77.8%-91.8%) than for HRI (72.8%-85.4%) on all HS grades for all studies used for corresponding MRI-PDFF values to HS grades.The results indicate that LiSA is more accurate than HRI in HS differentiation and can lead to more accurate grading of HS on NAFLD patients. read more
Citations
More filters
Journal ArticleDOI
Comparison of Visual Transient Elastography, Vibration Controlled Transient Elastography, Shear Wave Elastography and Sound Touch Elastography in Chronic liver Disease assessment using liver biopsy as 'Gold Standard'.
Ilias Gatos,Spyros Yarmenitis,I. Theotokas,John Koskinas,Emanuel K. Manesis,S. Zoumpoulis,Pavlos Zoumpoulis +6 more
TL;DR: In this article , a commercial alternative of USE, Visual Transient Elastography (ViTE), and to compare it with three established USE methods, VCTE, Shear Wave Elastograph (SWE) and Sound Touch Elastogram (STE), using Liver Biopsy (LB) as "Gold Standard".
Journal ArticleDOI
Feasibility of Ultrasound Attenuation Imaging for Assessing Pediatric Hepatic Steatosis
TL;DR: It is demonstrated that ATI can differentiate fatty liver from normal liver as well as moderate to severe fatty liverfrom mild fatty liver, and may be useful for identifying children who require liver biopsy and early treatment.
Journal ArticleDOI
Diagnostic efficiency on ultrasound shear wave elastography in evaluation of steatosis severity for non-alcoholic fatty liver disease: a rat model
Yusheng Wu,Qianjiao Liu,Yan Wang,Fangyan Li,Lawrence W. C. Chan,Yong Wen,Fan Yang,Yining Xiang,Qinghong Duan,Peng Luo,Pinggui Lei +10 more
TL;DR: In this article , the authors demonstrate the influence of steatosis on liver stiffness measured by shear wave elastography (SWE) on a rat model with NAFLD and analyze feasibility of SWE for grading steatotic in absence of fibrosis.
References
More filters
Journal ArticleDOI
Nonalcoholic fatty liver disease: From steatosis to cirrhosis
TL;DR: The present “gold standard” management of NASH is modest weight reduction, particularly correction of central obesity achieved by combining dietary measures with increased physical activity, which improves insulin resistance and reverses steatosis, hepatocellular injury, inflammation, and fibrosis.
Journal ArticleDOI
The utility of radiological imaging in nonalcoholic fatty liver disease
Sherif Saadeh,Zobair M. Younossi,Zobair M. Younossi,Erick M. Remer,Terry Gramlich,Janus P. Ong,Maja E. Hurley,Kevin D. Mullen,James N. Cooper,Michael J. Sheridan +9 more
TL;DR: Differences between NASH and nonprogressive NAFLD were not apparent with any radiological modality, and good intraobserver agreement was evident for each modality that was superior to interob Server agreement.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.
Journal ArticleDOI
Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection.
TL;DR: Multiple case reports and case reviews of HCC in the setting of NASH support the associations of diabetes and obesity with the risk of H CC, as well as suggest age and advanced fibrosis as significant risks.
Journal ArticleDOI
Non-alcoholic fatty liver disease - A global public health perspective.
TL;DR: Given the rapidly growing global burden of NAFLD and NASH, efforts must continue to find accurate non-invasive diagnostic and prognostic biomarkers, to develop effective treatments for individuals with advanced NASH and prevention methods for individuals at high risk of NA FLD and progressive liver disease.
Related Papers (5)
Prediction of Nonalcoholic Fatty Liver Disease Using Noninvasive and Non-Imaging Procedures in Japanese Health Checkup Examinees.
Kenichiro Murayama,Kenichiro Murayama,Michiaki Okada,Kenichi Tanaka,Chika Inadomi,Wataru Yoshioka,Yoshihito Kubotsu,Tomomi Yada,Hiroshi Isoda,Takuya Kuwashiro,Satoshi Oeda,Takumi Akiyama,Noriko Oza,Hideyuki Hyogo,Masafumi Ono,Takumi Kawaguchi,Takuji Torimura,Keizo Anzai,Yuichiro Eguchi,Hirokazu Takahashi +19 more